Imikhiqizo

I-Linagliptin Intermediate F, eyaziwa nangokuthi i-3-aminopiperidine-1-carboxylic acid, iyikhemikhali ebalulekile ekuhlanganisweni kwe-linagliptin, umuthi osetshenziselwa ukwelapha uhlobo 2 sikashukela i-mellitus.I-Linagliptin isekilasini lemithi eyaziwa ngokuthi yi-dipeptidyl peptidase-4 (DPP-4) inhibitors, esiza ukulawula amazinga kashukela egazini. I-Linagliptin Intermediate F idlala indima ebalulekile ezigabeni zokugcina zokwenziwa kwe-linagliptin.Isebenza njengesakhiwo esiyinhloko sokwakha isakhiwo samakhemikhali esiyingqayizivele se-linagliptin ngokwenza uchungechunge lokusabela.Lokhu okumaphakathi kusetshenziswa ngokukhethekile ekuhlanganisweni kweringi ye-piperidine ewumongo yesakhiwo samangqamuzana e-linagliptin. Uma isihlanganisiwe, i-linagliptin isebenza ngokuvimbela umsebenzi we-enzymatic we-DPP-4.Ama-DPP-4 inhibitors asebenza ngokuvimbela ukuwohloka kwamahomoni e-incretin, njenge-glucagon-like peptide-1 (GLP-1), anesibopho sokuvuselela ukukhululwa kwe-insulin nokucindezela ukukhiqizwa kweglucagon.Ngokuvimbela i-DPP-4, i-linagliptin yandisa ukusebenza kwala mahomoni e-incretin, okuholela ekulawuleni ushukela wegazi okuthuthukisiwe kubantu abanesifo sikashukela sohlobo 2. I-Linagliptin ngokuvamile inqunywa njengesengezo ekudleni nasekuzivocavoceni ekulawuleni uhlobo lwesifo sikashukela sohlobo 2.Kwaziwa ngesigamu sempilo ende, evumela ukuthi kube lula ukudosa kanye ngosuku.I-Linagliptin ikhonjiswe ukuthi yehlisa ngempumelelo amazinga e-hemoglobin A1c, okuwuphawu lokulawula ushukela wesikhathi eside, futhi ngokuvamile ibekezelelwa kahle iziguli. okungaba nomthelela omkhulu ezimpilweni zabantu abanesifo sikashukela sohlobo 2.Ngokufaka isandla ekwakhiweni kwesakhiwo samakhemikhali esiyingqayizivele se-linagliptin, lokhu okumaphakathi kwenza umkhiqizo wokugcina uvimbe ngempumelelo i-DPP-4 futhi uthuthukise ukulawulwa kwe-glycemic. Ekugcineni, i-Linagliptin Intermediate F iyinhlanganisela yamakhemikhali ebalulekile ekuhlanganisweni kwe-linagliptin, i-DPP-4 inhibitor. esetshenziselwa ukwelapha isifo sikashukela sohlobo 2.Iqhaza layo ekwakhiweni kwesakhiwo samangqamuzana e-linagliptin igcizelela ukubaluleka kwayo ekukhiqizeni umuthi ongathuthukisa ukulawula ushukela wegazi futhi uthuthukise ukuphathwa kwesifo sikashukela.Ngokuvimbela i-DPP-4, i-linagliptin isiza ukulawula amazinga kashukela egazini futhi ibe nomthelela enhlalakahleni yonke yabantu abanesifo sikashukela sohlobo 2.