Imikhiqizo

I-Lithium trifluoromethanesulfonate, eyaziwa nangokuthi i-LiOTf, iyi-reagent ebalulekile kanye ne-catalyst ku-organic synthesis.Kuwusawoti owenziwe inhlanganisela ye-lithium cations (Li+) kanye ne-trifluoromethanesulfonate anions (OTf-).I-LiOTf isetshenziswa kabanzi ekuphenduleni kwamakhemikhali okuhlukahlukene ngenxa yezakhiwo zayo eziyingqayizivele namandla okwenza kube lula uguquko olufiselekayo.Okunye kwezicelo eziyinhloko ze-lithium trifluoromethanesulfonate injenge-Lewis acid catalyst.Ingenza kusebenze amaqembu ahlukahlukene asebenzayo nama-substrates, ikhuthaze ukusabela okubandakanya ukwakheka kwamabhondi amasha.I-LiOTf iphumelela kakhulu ekwenzeni kusebenze amabhondi e-carbon-oxygen (CO), njengakusabela kwe-acetalization, lapho yenza kube lula ukwakheka kwama-acetals otshwaleni.Ingase futhi iqalise amanye amabhondi aqukethe i-heteroatom, njengamabhondi e-carbon-nitrogen (CN), evumela ukwakheka kwama-amide noma imines.Ukusetshenziswa kwe-LiOTf njenge-catalyst kuvumela izimo zokusabela ezithambile, izimfuneko eziphansi zamandla, kanye nokukhetha okuthuthukisiwe.I-LiOTf iphinde isetshenziswe njengomthombo wama-lithium cation ekuphenduleni okuhlukahlukene.I-Lithium iyiyoni yensimbi ewusizo engabamba iqhaza ekuphenduleni okuhlukahlukene, njengokusabela kokuhlangana kwe-metal-catalyzed kanye nokusabela kokushintshwa kwe-nucleophilic.I-LiOTf ihlinzeka ngomthombo olula notholakala kalula we-lithium walezi zinguquko.Ukwengeza, i-anion ye-trifluoromethanesulfonate ingasebenza njenge-counterion, ukulinganisa ukukhokhiswa kwe-lithium cation kanye nokuzinzisa ama-intermediates asebenzayo.Ngaphezu kwalokho, i-LiOTf ithola izinhlelo zokusebenza kukhemikhali yokwenziwa ngekhono layo lokuxazulula kanye nokuzinzisa abaxhumanisi abasebenzayo.Ingasebenza njengesinyibilikisi esixhumanisayo, esisiza ukusabela okubandakanya ama-transition metal catalysts noma ezinye izinhlobo ezisebenzayo.Ngaphezu kwalokho, i-LiOTf ivamise ukusetshenziswa njenge-electrolyte kumabhethri e-lithium-ion ngenxa yokuqina kwayo kanye nokusebenza okuphezulu kwe-ionic.Kubalulekile ukuqaphela ukuthi i-LiOTf kufanele iphathwe ngokuqapha ngenxa yokukwazi ukusebenza kabusha nokuvutha kwayo.Kufanele igcinwe endaweni epholile, eyomile, kude nomswakama kanye nemithombo yokushisa.Njengamanye usawoti we-lithium, i-LiOTf ibeka engcupheni yokubola okushisayo futhi ingakhiqiza intuthu enobuthi lapho ichayeke kumazinga okushisa aphezulu.I-Lewis acidity yayo, ikhono lokuhlinzeka nge-lithium cations, kanye nezakhiwo ezincibilikisayo kuyenza ibe wusizo ekuguqulweni kwamakhemikhali okuhlukahlukene.Kodwa-ke, kufanele kuthathwe izinyathelo ezifanele zokuphatha nokugcina ukuze kuqinisekiswe ukusetshenziswa kwayo ngokuphephile.