I-Metronidazole Cas: 443-48-1
| Inombolo Yekhathalogi | XD91888 |
| Igama Lomkhiqizo | I-Metronidazole |
| I-CAS | 443-48-1 |
| Ifomu le-Molecularla | I-C6H9N3O3 |
| Isisindo samangqamuzana | 171.15 |
| Imininingwane Yesitoreji | 2-8°C |
| Ikhodi Yentela Evumelanisiwe | 29332990 |
Ukucaciswa Komkhiqizo
| Ukubukeka | I-crystalline powder emhlophe |
| U-Asay | 99% iminithi |
| Iphoyinti lokuncibilika | 159-161 °C (okhanyisiwe) |
| Iphuzu elibilayo | 301.12°C (isilinganiso esinzima) |
| ukuminyana | 1.3994 (isilinganiso esinzima) |
| inkomba ye-refractive | 1.5800 (isilinganiso) |
| Fp | 9℃ |
| ukuncibilika | i-acetic acid: 0.1 M, icacile, iphuzi kancane |
| pka | pKa 2.62(H2O,t =25±0.2,Iundefined) (Akunasiqiniseko) |
| Ukuncibilika kwamanzi | <0.1 g/100 mL ku-20 ºC |
I-Metronidazole iyisidakamizwa esikhethwayo se-amebiases, i-vaginal trichomonasis kanye ne-trichlomonadic urethritis emadodeni, i-lambliosis, i-amebic dysentery, kanye nezifo ze-anaerobic ezibangelwa ama-microorganisms azwelayo emuthini.Omqondofana walesi sidakamizwa yi-flagyl, i-protostat, i-trichopol, ne-vagimid.
I-Metronidazole itholakala njengemithi yomlomo, ye-intravaginal, topical, kanye ne-parenteral.Ikhiqizwa izinkampani eziningana, kodwa itholakala kuphela ngencwadi kadokotela.Ukuchayeka kwemvelo okungahlosiwe akunakwenzeka, futhi uma kwenzeka, mancane kakhulu amathuba okuba kubangele ubuthi.
Isetshenziswa njenge-antibacterial ekwelapheni i-rosacea.I-Antiprotozoal (i-trichomonas).I-carcinogen yomuntu engaba khona.
I-Metronidazole iyi-ejenti elwa namagciwane kanye ne-antiprotozoal.Isetshenziselwa kakhulu ukwelapha noma ukuvimbela izifo zesistimu noma zendawo ezibangelwa amagciwane e-anaerobic, njengezifo ezibangelwa amagciwane e-anaerobic emgodini wesisu, umgudu wokugaya ukudla, uhlelo lokuzala lwabesifazane, umgudu wokuphefumula ophansi, isikhumba nezicubu ezithambile, amathambo namalunga, njll. , izifo ze-meningeal, kanye ne-colitis ebangelwa ukusetshenziswa kwama-antibiotic nakho kuyaphumelela.I-tetanus ivame ukwelashwa nge-tetanus antitoxin (TAT).Ingasetshenziselwa futhi ukutheleleka nge-anaerobic ngomlomo.Ngomhla zingama-27 kuMfumfu wezi-2017, uhlu lwama-carcinogens olushicilelwe yi-World Health Organization's International Agency for Research on Cancer lwahlungwa kuqala ukuze lusetshenziswe, futhi i-metronidazole yafakwa ohlwini lwe-carcinogens yesigaba 2B.NgoJanuwari 2020, i-metronidazole yakhethwa engxenyeni yesibili yohlu lukazwelonke lokuthengwa kwezidakamizwa.
I-Metronidazole iyi-ejenti ephumelela kunazo zonke etholakalayo ekwelapheni abantu abanazo zonke izinhlobo ze-amebiasis, mhlawumbe ngaphandle komuntu ongenazimpawu kodwa oqhubeka nokukhipha ama-cyst.Leso simo sidinga i-amebicide ye-intraluminal esebenzayo, njenge-diloxanide furoate, i-paromomycin sulfate, noma i-dioodohydroxyquin.I-Metronidazole iyasebenza ngokumelene nama-cysts amathumbu kanye nama-extraintestinal kanye nama-trophozoite.
Nakuba i-quinacrine hydrochloride isetshenziselwe ukwelapha i-giardiasis, odokotela abaningi bakhetha i-metronidazole.I-Furazolidone ingenye yokukhetha.
I-Metronidazole umuthi okhethwayo eYurophu wezifo ezibangelwa amagciwane;ukukhathazeka mayelana nokuba khona kwe-carcinogenicity kuholele ekuxwayiseni okuthile ekusetshenzisweni kwayo e-United States.Muva nje kutholakale ukuthi iyasebenza ekwelapheni izifo ze-D. medinensis (Guinea worm) kanye ne-Helicobacter pylori.
Ibuye isetshenziswe e-acne rosacea, i-balantidiasis kanye ne-Guinea worm infection.T. vaginalis izifo ezimelana nesilinganiso esivamile zidinga ukwelashwa okukhethekile.
