Imikhiqizo

I-N-[(2'-cyano[1,1'biphenyl]-4-yl)methyl]-methyl ester L-valine monohydrochloride umuthi ovame ukusetshenziswa ekwelapheni umfutho wegazi ophakeme, owaziwa nangokuthi umfutho wegazi ophakeme.Ingokwesigaba semithi ebizwa ngokuthi i-angiotensin-converting enzyme (ACE) inhibitors.Umfutho wegazi ophakeme yisimo esivamile esingandisa ingozi yezinkinga zempilo eziningi, okuhlanganisa nesifo senhliziyo, unhlangothi, nokulimala kwezinso.I-ACE inhibitors, njenge-N-[(2'-cyano[1,1'biphenyl]-4-yl)methyl]-methyl ester L-valine monohydrochloride, ivamise ukunikezwa ukusiza ukwehlisa umfutho wegazi nokunciphisa ubunzima enhliziyweni kanye imithambo yegazi.Indlela eyinhloko yokusebenza kwe-N-[(2'-cyano[1,1'biphenyl]-4-yl)methyl]-methyl ester L-valine monohydrochloride ivimbela umsebenzi we-angiotensin-converting enzyme (ACE). ).I-ACE inesibopho sokuguqula i-angiotensin I ibe i-angiotensin II, i-vasoconstrictor enamandla, enciphisa imithambo yegazi futhi inyuse umfutho wegazi.Ngokuvimbela i-ACE, lo muthi usiza ukuvimbela ukwakheka kwe-angiotensin II, okuholela ku-vasodilation (ukunwetshwa kwemithambo yegazi) kanye nokwehla komfutho wegazi.N--[(2'-cyano[1,1'biphenyl] -4-yl I-methyl]-methyl ester L-valine monohydrochloride ivamise ukuthathwa ngomlomo, ngokuvamile njengomthamo kanye ngosuku.Umthamo othize kanye nezikhathi zokuphatha kuzoncika ezintweni ezihlukahlukene, okuhlanganisa ukuqina komfutho wegazi ophakeme kanye nokusabela komuntu ekwelashweni.Lo muthi ungasetshenziswa wodwa noma uhlanganiswe neminye imithi elwa nomfutho wegazi ophezulu ukuze kuzuzwe ukulawulwa komfutho wegazi ophakeme.Kubalulekile ukuqaphela ukuthi i-N--[(2'-cyano[1,1'biphenyl]-4-yl)methyl]-methyl I-ester L-valine monohydrochloride ingase ibangele imiphumela ethile engemihle kwabanye abantu.Imiphumela emibi evamile ihlanganisa isiyezi, ikhanda elibuhlungu, ukukhwehlela okomile, nokukhathala.Uma le miphumela engemihle iqhubeka noma ikhathaza, kutuswa ukuthi uthintane nochwepheshe bezempilo.Ezimweni ezingavamile, kungase kube nemiphumela emibi kakhulu, njengokungezwani komzimba, izinkinga zezinso, noma i-angioedema (ukuvuvukala okukhulu kobuso, izindebe, umphimbo, noma ulimi).Uma kwenzeka noma yimiphi imiphumela emibi kakhulu, kufanele kufunwe usizo lwezokwelapha ngokushesha.Ngaphambi kokuqala i-N-[(2'-cyano[1,1'biphenyl]-4-yl)methyl]-methyl ester L-valine monohydrochloride, kubalulekile. ukudalula noma yiziphi izimo zezokwelapha ezikhona noma ukungezwani komzimba kudokotela omnikezayo.Umuthi ungase ungafaneleki kubantu abanomlando wesifo sezinso, isifo sesibindi, noma isifo senhliziyo, njengoba kungase kube nzima kakhulu lezi zimo. -yl)methyl]-methyl ester L-valine monohydrochloride iyi-ACE inhibitor esetshenziselwa ukwelapha umfutho wegazi ophezulu.Ngokuvimbela i-ACE, isiza ekwandiseni imithambo yegazi nokwehlisa umfutho wegazi.Ukunamathela imithamo enqunyiwe, ukulandelelwa njalo nochwepheshe bezokunakekelwa kwempilo, kanye nokuqapha imiphumela engemihle engaba khona kubalulekile ekusetshenzisweni okuphephile nangempumelelo kwalo muthi.Kubalulekile futhi ukugcina indlela yokuphila enempilo, okuhlanganisa ukuvivinya umzimba njalo, ukudla okunomsoco, nokulawula ukucindezeleka, ukuze uqhubeke nokweseka ukulawula umfutho wegazi.