Imikhiqizo

I-Nicotinamide Riboside ingasetshenziswa ocwaningweni lwebhayoloji lwe-gene circadian reprogramming transcriptome esibindini esikhonjwe izindlela zokuguga zokuguga kumagundane.Iphinde ikhulise i-NAD+ ku-cerebral cortex futhi inciphise ukuwohloka kwengqondo kumodeli yegundane ye-transgenic yesifo i-Alzheimer's.

I-Nicotinamide adenine dinucleotide (NAD+) iyi-coenzyme ebucayi okuthi, uma yehliselwa ku-NADH, isebenze njenge-ejenti enciphisayo ukunikela ngama-electron we-oxidative phosphorylation kanye nokuhlanganiswa kwe-ATP ku-mitochondria.I-NAD+ iyi-cofactor ebalulekile yama-enzyme afana ne-sirtuins, i-ADP-ribosyltransferases (ARTs), ne-Poly [ADP-ribose] polymerases (PARPs) futhi isetshenziswa ngokuqhubekayo yilawa ma-enzyme.Isilinganiso se-NAD+/NADH siyingxenye ebalulekile yesimo se-redox seseli.(Verdin 2015).Ngokwezibalo ezithile, i-NAD noma i-NADP ehlobene ibamba iqhaza engxenyeni yesine yakho konke ukusabela kwamaselula (Opitz Heiland 2015).Kukhona amagumbi ahlukene e-NAD+ ku-nucleus, mitochondria, ne-cytoplasm (Verdin 2015).
I-Nicotinamide riboside (NR) ingaguqulelwa ku-NAD+ ngesinyathelo esimaphakathi lapho iguqulwa ibe yi-nicotinamide mononucleotide (NMN) nge-NR kinase (Nrk) bese iba yi-NAD+ ngama-NMNAT.I-NR ngokwemvelo itholakala kokunye ukudla kodwa ngamanani aphansi kakhulu (isb. uhla lwama-micromolar aphansi).Ngokomlando, i-NR bekunzima ukuyithola ngamanani amakhulu ahlanziwe, kodwa ngenxa yentuthuko yezindlela zokuhlanganisa (Yang 2007), kusukela ngo-June 2013, ithengiswa njengesengezo sokudla.