i-p-hydoxybenzoic acid, i-monosodium Cas: 114-63-6 99% Okumhlophe kuya kokuquleka okuphuzi noma okumhlophe okuyi-crystalline powder
| Inombolo Yekhathalogi | XD90141 |
| Igama Lomkhiqizo | i-p-hydoxybenzoic acid, i-monosodium |
| I-CAS | 114-63-6 |
| I-Molecular Formula | C7H5O3Na |
| Isisindo samangqamuzana | 160.10 |
| Imininingwane Yesitoreji | I-ambient |
| Ikhodi Yentela Evumelanisiwe | 2918290000 |
Ukucaciswa Komkhiqizo
| Ukubukeka | Okumhlophe kuya kokuqulekile okuphuzi noma okumhlophe okucwebezelayo okuyimpushana |
| U-Asay | ≥ 99% |
| Ukuminyana | 1.3750 |
| Iphoyinti lokuncibilika | >300 °C(lit.) |
| Iphuzu elibilayo | 336.2°Cat760mmHg |
| Iphoyinti le-Flash | 171.3°C |
Ukuvinjelwa kwe-β-carbonic anhydrases (CAs, EC 4.2.1.1) kusuka kusikhunta se-pathogenic Cryptococcus neoformans (Can2) kanye ne-Candida albicans (Nce103) enochungechunge lwama-branched aliphatic kanye ne-aromatic carboxylates angu-25 kuye kwaphenywa.Ama-isoforms abantu i-hCA I kanye ne-II nawo afakiwe ocwaningweni ukuze aqhathaniswe.I-aliphatic carboxylates ngokuvamile yayiyi-millimolar hCA I ne-II inhibitor kanye ne-micromolar/submicromolar β-CA inhibitor ephansi.Ama-carboxylates anephunga elimnandi ayengama-micromolar inhibitor ama-enzyme amane kodwa amanye awo abonisa umsebenzi ophansi we-nanomolar ngokumelene nama-enzyme e-pathogenic fungal.I-4-Hydroxy- kanye ne-4-methoxy-benzoate evinjiwe i-Can2 ene-K(I)s ka-9.5-9.9 nM.I-methyl esters, i-hydroxamates, i-hydrazides kanye ne-carboxamides yezinye zalezi zinto eziphuma ku-derivative nazo zazingama-inhibitor asebenzayo e-α- kanye ne-β-CAs aphenywa lapha.
Ama-Parabens aphakathi kwezivimbeli ezisetshenziswa kakhulu ukuvimbela ukukhula kwamagciwane kanye nokwelula impilo yeshalofu yohlu lwemikhiqizo yabathengi.Inhloso yocwaningo lwamanje kwakuwukuthola ukuqonda mayelana nokusetshenziswa kwama-parabens kumangqamuzana omdlavuza webele (MCF7) njengoba abonise umsebenzi we-estrogenic kulawa maseli futhi atholwe ezicutshini zomdlavuza webele.Ubuthi be-parabens kumaseli e-MCF7 bunqunywe kusetshenziswa ukuhlolwa kwe-MTT.I-Hydrolysis ye-methyl-, butyl kanye ne-benzyl-paraben ku-p-hydroxybenzoic acid yahlaziywa kumaseli e-MCF7 akhulisiwe kanye nama-homogenates eselula.I-Glucuronidation ne-sulfoconjugation yafundwa kuma-homogenates e-MCF7, futhi ama-parabens ahlaziywa yi-HPLC.I-Methyl-paraben iboniswe ukuthi inobuthi obuncane kakhulu kune-butyl ne-benzyl-paraben.AmaParabens ayezinzile ngokuphelele kuma-homogenates e-MCF7 kuyilapho i-p-nitrophenyl acetate, uhlobo lwe-substrate, lwenziwa i-hydrolysis.Ama-homogenates amaseli e-MCF7 awazange aveze imisebenzi ye-glucuronidation ne-sulfoconjugation kuma-parabens.Ukuzinza okuphezulu kwama-parabens kungase kuchaze ukuqoqwa kwawo ezicubu zomdlavuza webele.
![N-[[bis[4-(dimethylamino)phenyl]amino]carbonyl] glycine sodium usawoti Okumhlophe kuya kokumpunga okuluhlaza ngokumpunga okuyikristalu](http://cdn.globalso.com/xdbiochems/115871-19-7.jpg)
