Isixazululo se-Poly-L-lysine ( 0.1%) I-Cas: 25988-63-0
| Inombolo Yekhathalogi | XD90306 |
| Igama Lomkhiqizo | Isixazululo se-Poly-L-lysine ( 0.1%) |
| I-CAS | 25988-63-0 |
| I-Molecular Formula | I-C18H38N6O4 |
| Isisindo samangqamuzana | 402.532124042511 |
| Imininingwane Yesitoreji | 2-8°C |
Ukucaciswa Komkhiqizo
| Isivivinyo | 0.1% |
| Ukubukeka | Uketshezi olungenambala |
Izinguquko ze-eucine-rich repeat kinase 2 (LRRK2) ziyimbangela eyaziwa kakhulu ye-Parkinson's disease (PD).Izici zomtholampilo ze-LRRK2 PD azihlukaniseki ku-idiopathic PD, nokunqwabelana kwe-α-synuclein kanye/noma i-tau kanye/noma i-ubiquitin kuma-intraneuronal aggregates.Lokhu kuphakamisa ukuthi i-LRRK2 iwukhiye wokuqonda i-aetiology ye-disorder.Nakuba ukulahlekelwa komsebenzi kungabonakali njengendlela ebangela i-PD ezigulini ze-LRRK2, akucaci ukuthi le phrotheni ilamula kanjani ubuthi.Kulolu cwaningo, sibika ukuthi i-LRRK2 overexpression kumaseli kanye ne-vivo iphazamisa umsebenzi we-ubiquitin-proteasome pathway, nokuthi lokhu kubangela ukuqoqwa kwama-substrates ahlukahlukene ane-LRRK2 overexpression.Sibonisa ukuthi lokhu akulamulwa yi-LRRK2 enkulu noma ukulandelwa kwe-ubiquitin ekuhlanganiseni.Okubalulekile, ukungajwayelekile okunjalo akubonakali ngokuvezwa ngokweqile kweprotheni ehlobene i-LRRK1.Idatha yethu iphakamisa ukuthi i-LRRK2 ivimbela ukucaciswa kwe-proteasome substrate phezulu komsebenzi we-proteasome catalytic, ivuna ukunqwabelana kwamaprotheni kanye nokwakheka kweqoqo.Ngakho, sinikeza isixhumanisi samangqamuzana phakathi kwe-LRRK2, imbangela eyaziwa kakhulu ye-PD, kanye ne-phenotype yayo echazwe ngaphambilini yokuqoqwa kwamaprotheni.
