I-Polymyxin B sulfate CAS: 1405-20-5 Impuphu emhlophe
| Inombolo Yekhathalogi | XD90360 |
| Igama Lomkhiqizo | I-Polymyxin B sulfate |
| I-CAS | 1405-20-5 |
| I-Molecular Formula | I-C55H96N16O13 · 2H2SO4 |
| Isisindo samangqamuzana | 1385.61 |
| Imininingwane Yesitoreji | 2 kuya ku-8 °C |
| Ikhodi Yentela Evumelanisiwe | 29419000 |
Ukucaciswa Komkhiqizo
| Isiphetho | Ihambisana ne-USP35 |
| Izinsimbi ezinzima | <20ppm |
| pH | 5-7 |
| Ukuhlonza | I-chromatography ye-Liquid: iyavumelana |
| Isivivinyo | 99% |
| Ukubukeka | Impushana emhlophe |
| Ukulahlekelwa Ekumisweni | <6% |
| Ukuncibilika | Incibilika ngokukhululeka emanzini, inyibilika kancane ku-Ethanol |
| I-sulfate | 15.5% - 17.5% |
| Usayizi Wezinhlayiyana | <30µm |
| Ukujikeleza okuqondile okubonakalayo | -78° -90° |
| Phenylalanine | 9.0%-12.0% |
| Ama-Pyrogens | Ihlangabezana nezidingo |
| Umlotha one-sulfate | <0.75% |
| Isibalo se-aerobic esisebenzayo | <100cfu/g |
| Amandla | > 6500 IU/mg |
I-ExPortal protein secretion organelle ku-Streptococcus pyogenes iyi-anionic phospholipid-containing membrane microdomain ethuthukiswe ku-Sec translocons kanye ne-postsecretion protein biogenesis factor.I-Polymyxin B ibopha futhi iphazamise ubuqotho be-ExPortal, okuholela ekukhiqizweni okunesici kobuthi abambalwa.Ukuthola ukuqonda ezintweni ezithonya inhlangano ye-ExPortal, isikrini sofuzo senziwa ukuze kukhethwe eziguquguqukayo ezizenzakalelayo ze-polymyxin B ezibonisa ubuqotho obuthuthukisiwe be-ExPortal.Ukulandelanisa kabusha kwegenome okuphelele kwama-25 aphikisayo okuguquguqukayo kwembulwe kusukela kokukodwa kuya kwezine ku-mutant genome ngayinye ehlanganiswe ngokuyinhloko phakathi kwesethi eyinhloko yamaqembu ofuzo ayi-10.Ukwakhiwa kwezinto eziguquliwe ezinokususwa ngakunye noma okufakiwe kubonise ukuthi izakhi zofuzo ezingu-7 eziyinhloko zinikeza ukumelana nobuqotho obuthuthukisiwe be-ExPortal ngokulahlekelwa umsebenzi, kuyilapho oku-3 kungenzeka kube ngenxa yenzuzo yokusebenza kanye/noma imiphumela ehlangene.Izakhi zofuzo eziqinile zihlanganisa isilawuli esibhalwe phansi se-lipid biosynthesis, izakhi zofuzo eziningana ezihilelekile ekutholeni izakhi zofuzo, kanye nezinhlobonhlobo zezakhi zofuzo ezihilelekile ekuphenduleni ingcindezi.Amalungu amabili esigaba sokugcina nawo asebenza njengabalawuli abanoveli be-SpeB cysteine protease eyimfihlo.Ukuhlaziywa kokuguqulwa okuvame kakhulu okuhlukanisiwe, ukususwa kwe-nucleotide eyodwa kuthrekhi yezinsalela ze-adenine ezingu-9 ezilandelanayo ku-pstS, okuhlanganisa ingxenye ye-Pi transporter ehambisanayo ephezulu, iphakamisa ukuthi lokhu kulandelwana kusebenza njengokushintshwa kwamangqamuzana ukuze kube lula ukuzivumelanisa nokucindezeleka.Ngokuhlangene, le datha iphakamisa ukuba khona kwempendulo yokucindezeleka kwe-membrane ekhuthaza ubuqotho obuthuthukisiwe be-ExPortal kanye nokumelana nama-peptide e-cationic antimicrobial.
