I-Rapamycin evela ku-Streptomyces hygroscopicus CAS:53123-88-9 Okumhlophe kuya kokumhlophe noma okuphuzi okuyi-crystalline powder
| Inombolo Yekhathalogi | XD90356 |
| Igama Lomkhiqizo | I-Rapamycin evela ku-Streptomyces hygroscopicus |
| I-CAS | 53123-88-9 |
| I-Molecular Formula | I-C51H79NO13 |
| Isisindo samangqamuzana | 914.17 |
| Imininingwane Yesitoreji | -20 °C |
| Ikhodi Yentela Evumelanisiwe | 2942000000 |
Ukucaciswa Komkhiqizo
| Isivivinyo | 99% |
| Ukubukeka | Impushana yekristalu emhlophe ukuya kokumhlophe noma ephuzi |
I-Rapamycin, isidakamizwa esiye saboniswa ukwandisa isikhathi sokuphila kumagundane, ivimbela umgomo we-rapamycin (TOR), umzila omkhulu olawula ukukhula kwamangqamuzana nesimo samandla.Kucatshangelwa ukuthi i-rapamycin kanye ne- dietary restriction (DR) yandisa isikhathi sokuphila ngokusebenzisa izindlela/izindlela ezifanayo.Sisebenzisa ukuhlaziywa kwe-microarray, siqhathanise i-transcriptome yezicubu ze-adipose ezimhlophe ezivela kumagundane afunzwe i-rapamycin noma i-DR-diet izinyanga ezingu-6.Ukuhlaziywa kwe-multidimensional scaling kanye ne-heatmap kubonise ukuthi i-rapamycin empeleni yayingenawo umthelela ku-transcriptome uma iqhathaniswa ne-DR.Isibonelo, imibhalo ebhaliwe eyisithupha kuphela eyashintshwa kakhulu yi-rapamycin ngenkathi amagundane aphakelwa i-DR abonisa ushintsho olubalulekile emibhalweni engaphezu kwe-1000.Sisebenzisa ukuhlaziya indlela yobuhlakani, sithole ukuthi i-stearate biosynthesis kanye nokusayina kwesigqi se-circadian kwashintshwa kakhulu yi-DR.Ukuthola kwethu okubonisa ukuthi i-DR, kodwa hhayi i-rapamycin, inomphumela ku-transcriptome yezicubu ze-adipose, okuphakamisa ukuthi lezi zindlela ezimbili zokukhwabanisa zandisa isikhathi sokuphila ngokusebenzisa izindlela/izindlela ezahlukene.
