Imikhiqizo

I-Rosuvastatin Intermediates ZD9, eyaziwa nangokuthi i-Z-4-(4-Fluorophenyl)-6-Isopropyl-2--[(N-Methyl-N-Methylsulfonyl)Amino]Pyrimidin-5-Yl, iyinhlanganisela yamakhemikhali esebenza njengento ebalulekile. Okuphakathi ekuhlanganiseni komuthi okwehlisa i-cholesterol iRosuvastatin.Lokhu okumaphakathi kudlala indima ebalulekile ekukhiqizweni kwe-Rosuvastatin, eyingxenye yezidakamizwa ezaziwa ngokuthi ama-statins.I-ZD9 isebenza njengesandulela ekuhlanganiseni kwe-rosuvastatin ngezinyathelo eziningi.Ngesikhathi senqubo yokukhiqiza, i-ZD9 iba nokuguqulwa kwamakhemikhali okuhlukahlukene ukuze ekugcineni ikhiqize umkhiqizo wokugcina, i-Rosuvastatin.Lokhu kuhlanganiswa kuhilela ukunamathiselwa kwamaqembu asebenzayo engeziwe ku-molecule ye-ZD9, okuholela ekwakhekeni kwesithako esisebenzayo semithi, i-Rosuvastatin.Rosuvastatin isetshenziswa kabanzi ekwelapheni i-hypercholesterolemia, isimo esibonakala ngamazinga aphezulu e-cholesterol egazini.Isebenza ngokuvimbela i-enzyme i-HMG-CoA reductase, edlala indima ebalulekile ekuhlanganisweni kwe-cholesterol emzimbeni.Ngokunciphisa ukukhiqizwa kwe-cholesterol, i-Rosuvastatin isiza ukwehlisa amazinga e-cholesterol jikelele, kuhlanganise ne-low-density lipoprotein (LDL) cholesterol, ngokuvamile ebizwa ngokuthi i-cholesterol "embi". kanye nendlela ephumelelayo.Isebenza njengesakhiwo esibhekana nochungechunge lokusabela kwamakhemikhali, okuholela ekwakhekeni kwezibopho ezithile kanye namaqembu asebenzayo adingekayo emsebenzini we-pharmacological we-Rosuvastatin.Ukuhlanganiswa kwe-Rosuvastatin kuyinqubo eyinkimbinkimbi, futhi okuphakathi ngakunye, okuhlanganisa i-ZD9, kubalulekile ekuqinisekiseni. ukwakheka okufanele komkhiqizo wokugcina.Ngaphandle kwe-ZD9, ukuhlanganiswa kwe-Rosuvastatin bekungeke kwenzeke, okuvimbe ukukhiqizwa kwalo muthi obalulekile owehlisa i-cholesterol. Kafushane, i-Rosuvastatin Intermediates ZD9 isebenza njengendawo ebalulekile ekuhlanganisweni komuthi osetshenziswa kabanzi wokwehlisa i-cholesterol, i-Rosuvastatin.Isebenza njengesakhiwo esibhekana nokuguqulwa kwamakhemikhali ukuze ekugcineni ikhiqize isithako esisebenzayo semithi.Ngokudlala indima ebalulekile enqubweni yokukhiqiza, i-ZD9 inikela ekutholakaleni komuthi obalulekile wokwelapha amazinga aphezulu e-cholesterol ezigulini.