Imikhiqizo

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine iyinhlanganisela ye-chiral enezinhlelo zokusebenza ezihlukahlukene emkhakheni wezokwelapha.Ukusetshenziswa okukodwa okubalulekile kwe-(S)-(-) -N,N-Dimethyl-3-hydroxy-3-(2-thienyl) propanamine is in the development of selective serotonin reuptake inhibitors (SSRIs).Ama-SSRI yikilasi lezidakamizwa ezivame ukusetshenziselwa ukwelapha ukudangala, ukuphazamiseka kokukhathazeka, nezinye izimo zempilo yengqondo.Le nhlanganisela isebenza njengesandulela noma into yokuqala ekuhlanganisweni kwe-serotonin reuptake inhibitors ekhethiwe, okuvumela ukuthuthukiswa kwama-enantiomers athile anezakhiwo ezithuthukisiwe zokwelapha.Ngokuhlanganisa i-(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine esakhiweni somuthi, abacwaningi bangakwazi ukulungisa izakhiwo zayo zemithi, njengokuhlobana kwayo nabathuthi be-serotonin, okuholela ekusebenzeni okuthuthukisiwe kanye nemiphumela emibi encishisiwe.Ukwengeza, (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl) propanamine ingasetshenziswa njengebhulokhi yokwakha ekuhlanganiseni kwezinye izinto eziphilayo. izinhlanganisela.Imvelo yayo ye-chiral kanye nesakhiwo esiguquguqukayo siyenza ibe yinto ebalulekile yokuqala yokwakha ama-molecule ayinkimbinkimbi.Abacwaningi bangakwazi ukusebenzisa amasayithi ahlukahlukene ku-molecule ukuze bethule amaqembu ahlukene noma baguqule i-stereochemistry ukuze bakhe abantu abasha abakhetha izidakamizwa. Ngaphezu kwalokho, (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine iye yafundelwa ukusetshenziswa kwayo okungase kube khona ekwelapheni isifo sikaParkinson.Ucwaningo luye lwabonisa ukuthi le nhlanganisela ibonisa umsebenzi we-dopamine agonist, okusho ukuthi ingashukumisa ama-dopamine receptors, avame ukuthinteka ku-Parkinson's disease.Ingase ibe namandla okwelapha ekudambiseni izimpawu ezihambisana nalesi sifo se-neurodegenerative.Kubalulekile ukuqaphela ukuthi (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl) propanamine inamandla inhlanganisela, futhi ukusetshenziswa kwayo kufanele kuphathwe ngokuqapha.Abacwaningi nochwepheshe abasebenza nale nhlanganisela kudingeka bathobele imihlahlandlela nezinqubo zokuphepha ukuze baqinisekise ukuphathwa ngendlela efanele futhi banciphise ubungozi.Kafushane, (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl ) i-propanamine iyinhlanganisela ebalulekile ekuthuthukisweni kwama-serotonin reuptake inhibitors akhethiwe kanye namanye ama-molecule e-bioactive.Imvelo yayo ye-chiral, ukwakheka okuguquguqukayo, kanye nemisebenzi yokwelapha engaba khona iyenza ibe yisakhiwo esibalulekile ocwaningweni lwezemithi.Ukucwaninga okuqhubekayo nokuhlola kwe-(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl) propanamine kungaba nomthelela ekwakhiweni kwezidakamizwa ezisanda kuzalwa kanye nokwelashwa okungaba khona kwezifo ezihlukahlukene.