Imikhiqizo

I-Silver trifluoromethanesulfonate, eyaziwa nangokuthi i-AgOTf, iyi-reagent enamandla futhi eguquguqukayo esetshenziswa ekuguquleni amakhemikhali okuhlukahlukene.Ingokwesigaba se-metal triflates, ewusizo kakhulu ekuhlanganiseni kwezinto eziphilayo ngenxa ye-acidity ye-Lewis kanye nekhono lokuvula ama-substrates.Okunye kwezicelo eziyinhloko ze-trifluoromethanesulfonate yesiliva injenge-catalyst in organic reactions.Ingenza kube lula ukuguqulwa okuhlukahlukene, okuhlanganisa ukusabela kwe-carbon-carbon bond, njenge-Friedel-Crafts alkylation and acylation reactions, kanye nokusabela kokwakheka kwebhondi ye-carbon-nitrogen, njenge-N-acylation yama-amine noma ukuhlanganiswa kwama-amide.Imvelo ye-Lewis acidic ye-AgOTf iyenza ikwazi ukusebenzisana nama-electron-rich rich, okuholela ekusebenziseni amabhondi amakhemikhali athile kanye nokwenza lula ukusabela okufunayo.Umsebenzi wayo okhuthazayo ubaluleke kakhulu ekuhlanganisweni kwemithi, amakhemikhali ezolimo, namakhemikhali amahle.I-AgOTf iwusizo futhi ekukhuthazeni ukuhlela kabusha nokusabela kokuhamba ngamabhayisikili.Ingakwazi ukuvuselela ukusabela okuhlukahlukene kokuhlela kabusha, njengokuhlelwa kabusha kuka-Beckmann, okuguqula ama-oxime abe ama-amide noma ama-ester, noma ukuhlelwa kabusha kwama-allic alcohols akhe izinhlanganisela ze-carbonyl.Ukwengeza, ingasiza ekuphenduleni kokuhamba ngebhayisikili, inike amandla ukwakheka kwamakhompiyutha angama-cyclic anezinhlelo zamandandatho eziyinkimbinkimbi.Uhlamvu lwe-Lewis olune-acidic lwe-AgOTf ludlala indima ebalulekile kulokhu kusabela ngokwenza lula ukuhlelwa kabusha kwebhondi nezinyathelo zokujikeleza. Ngaphezu kwalokho, i-trifluoromethanesulfonate eyisiliva isetshenziswa ekwenzeni kusebenze amabhondi e-carbon-hydrogen (CH).Ingenza kusebenze amabhondi angu-CH ancikene namaqembu asebenzayo, njengasekusebenzeni kwamabhondi e-CH anephunga elimnandi noma ukwenziwa kusebenze kwe-allylic noma i-benzylic CH bond.Lokhu kuvula kuvumela ukusebenza okulandelayo kwebhondi ye-CH, okuholela ekwakhekeni kwebhondi entsha ye-carbon-carbon noma i-carbon-heteroatom.Le ndlela, eyaziwa ngokuthi i-CH activation, iyinkambu ekhula ngokushesha ekuhlanganiseni kwezinto eziphilayo futhi inikeza umzila ophumelelayo wokufinyelela izikafula eziyinkimbinkimbi zamangqamuzana.Kuyaphawuleka ukuthi i-AgOTf izwela umswakama nomoya, ngakho kufanele isingathwe ngaphansi kwezimo ezilawulwayo.Ngokuvamile isetshenziswa ngamanani amancane, njengamanani e-catalytic, ngenxa yokusebenza kwayo kabusha okuphezulu.Kufanele kuqashelwe ukusebenza endaweni enomoya omuhle futhi kuvikelwe i-reagent ekuchayekeni kumswakama.Kafushane, i-silver trifluoromethanesulfonate (AgOTf) iyi-reagent ebalulekile kanye ne-catalyst ku-organic synthesis.Imvelo yayo ye-Lewis acidic iyenza isebenze ama-substrates, ikhuthaze ukuhlela kabusha kanye nokusabela kwe-cyclization, futhi ivule amabhondi e-CH, okuholela ekwakhekeni kwama-molecule ezinto eziphilayo eziyinkimbinkimbi.Kodwa-ke, izinyathelo zokuphepha kufanele zithathwe lapho kusingathwa futhi kugcinwe i-AgOTf ukuze kuqinisekiswe ukuzinza kwayo futhi kuvinjwe ukusabela okungafuneki.