Imikhiqizo

I-Sitagliptin umuthi oyingxenye yezidakamizwa ezibizwa ngokuthi i-dipeptidyl peptidase-4 (DPP-4) inhibitors.Isetshenziswa kakhulu ekwelapheni uhlobo 2 sikashukela mellitus.Isifo sikashukela senzeka lapho umzimba ungakwazi ukulawula kahle amazinga kashukela egazini, okuholela emazingeni aphezulu eglucose egazini.I-Sitagliptin isebenza ngokuvimbela i-DPP-4 enzyme, enesibopho sokuphula amahomoni e-incretin.Lawa mahomoni akhulisa ukukhiqizwa kwe-insulin futhi anciphisa ukukhiqizwa kweglucagon, ekugcineni okuholela emazingeni kashukela alawulwa kakhulu.Ngokuvimbela i-enzyme ye-DPP-4, i-sitagliptin ivumela amahomoni e-incretin ukuthi ahlale esebenza isikhathi eside, ngaleyo ndlela enze ngcono ukulawula ushukela wegazi.Indlela eyinhloko yokuphatha i-sitagliptin ngomlomo, futhi ingathathwa ngokudla noma ngaphandle.Umthamo onqunywe uchwepheshe wezempilo uzoncika ezintweni zesiguli ngasinye, njengobunzima besifo sikashukela neminye imithi esetshenziswayo.Kubalulekile ukulandela imiyalo ebekiwe ngokucophelela futhi ungalungisi umthamo ngaphandle kokuthintana nomhlinzeki wezempilo.I-Sitagliptin ivame ukusetshenziswa njengesengezo ekudleni nasekuzivivinyeni ekulawuleni uhlobo lwesifo sikashukela sohlobo 2.Ivame ukunqunywa ngokuhambisana nokuguqulwa kwendlela yokuphila neminye imithi elwa noshukela, njenge-metformin.Ngokuhlanganisa izindlela ezihlukene zokwenza, ezifana ne-sitagliptin's DPP-4 inhibition kanye nokwenza ngcono kwe-metformin ekuzweleni kwe-insulin, kungafinyelelwa ukulawulwa okungcono kwe-glycemic. Ukusebenza kwe-sitagliptin ekulawuleni amazinga kashukela kuye kwaboniswa ezivivinyweni eziningi zomtholampilo.Ucwaningo luye lwabonisa ukuthi ingakwazi ukwehlisa kokubili amazinga kashukela wokuzila ukudla kanye nangemuva kokudla (ngemuva kokudla), yehlise amazinga e-glycated hemoglobin (HbA1c), futhi ithuthukise ukulawulwa kwe-glycemic kukonke. njengekhanda elibuhlungu, izifo zepheshana lokuphefumula eliphezulu, nokuphazamiseka kwamathumbu njengokucanuzela kwenhliziyo noma isifo sohudo.Njenganoma yimuphi umuthi, ukungezwani komzimba okubi kakhulu kanye nemiphumela engemihle engavamile kodwa embi kakhulu kungenzeka, ngakho-ke kubalulekile ukubika noma yiziphi izimpawu ezingajwayelekile noma ezinzima kuchwepheshe wezempilo ngokushesha. .Njenge-DPP-4 inhibitor, isiza ukuthuthukisa ukulawulwa kwe-glycemic ngokwandisa umsebenzi wama-incretin hormone.Uma isetshenziswa ngokuhambisana nokuguqulwa kwendlela yokuphila neminye imithi elwa noshukela, i-sitagliptin ingaba ithuluzi eliphumelelayo lokulawula amazinga kashukela egazini kanye nokulawula uhlobo lwesifo sikashukela sohlobo 2.Ukuqapha nokubonisana nomhlinzeki wezempilo kubalulekile ukuze kube nemiphumela emihle.