Imikhiqizo

Isifo sikashukela i-mellitus sihlobene nokuvuvukala okungapheli okusezingeni eliphansi kanye nengcindezi ye-oxidative.I-Bupleurum Polysaccharides (BPs), ehlukanisiwe ne-Bupleurum smithii var.I-parvifolium ine-anti-inflammatory and anti-oxidative properties.Nokho, kuncane okwaziwayo ngemiphumela yako yokwelapha isifo sikashukela.Kulokhu kuhlolwa, imiphumela ye-BPs ekunciphiseni isifo sikashukela kanye nezindlela eziyisisekelo zaphenywa.Imodeli yamagundane esifo sikashukela yasungulwa ngemijovo elandelanayo ye-intraperitoneal ye-streptozotocin (100 mg/kg isisindo somzimba) izinsuku ezimbili.Amagundane anamazinga eglucose egazi angaphezulu kuka-16.8mmol/L akhethelwe ukuhlolwa.Amagundane anesifo sikashukela ayephathwa ngomlomo nge-BPs (30 kanye ne-60 mg/kg) kanye ngosuku izinsuku ezingama-35.Ama-BP awazange anciphise kakhulu amazinga kashukela egazini kuphela, kodwa futhi andise lawo e-serum insulini kanye ne-glycogen yesibindi kumagundane anesifo sikashukela uma kuqhathaniswa namagundane ayimodeli.Ukwengeza, ukuphathwa kwe-BPs kuthuthukise ukubonakaliswa kwe-insulin futhi kwacindezela i-apoptosis kuma-pancreas amagundane esifo sikashukela.Ukuhlolwa kwe-Histopathological kuphinde kwabonisa ukuthi ama-BP avikela amanyikwe nesibindi emonakalweni we-oxidative nokuvuvukala.Le miphumela iphakamisa ukuthi ama-BP avikela amaseli e-pancreatic β kanye nama-hepatocyte esibindi futhi athuthukise isifo sikashukela, esihlotshaniswa nezici zayo zokulwa ne-oxidative kanye ne-anti-inflammatory.