Imikhiqizo

I-T-Butyl-(3R,5S) -6-hydroxy 3,5-O-isopropylidene 3,5-dihydroxyhexanoate iyinhlanganisela yamakhemikhali enesakhiwo esiyinkimbinkimbi esivame ukusetshenziselwa ukuhlanganiswa kwezinto eziphilayo kanye neqembu elivikelayo kumakhemikhali e-carbohydrate.Kuyaziwa ngekhono layo lokuvikela ngempumelelo amaqembu e-hydroxyl nokuvimbela ukusabela okungafuneki phakathi nokuguqulwa kwamakhemikhali okuhlukahlukene.Okunye ukusetshenziswa okuyinhloko kwe-T-butyl-(3R,5S) -6-hydroxy 3,5-O-isopropylidene 3,5- I-dihydroxyhexanoate isekuhlanganiseni kwezinhlanganisela eziphilayo eziyinkimbinkimbi.Amaqembu e-Hydroxyl asebenza kakhulu futhi angabhekana nokusabela okungafuneki ngesikhathi sokuguqulwa kwamakhemikhali.Ngokuvikela ngokukhetha lawa maqembu nge-T-butyl-(3R,5S)-6-hydroxy 3,5-O-isopropylidene 3,5-dihydroxyhexanoate moiety, osokhemisi bangakwazi ukulawula ukusabela futhi bathole imikhiqizo efiselekayo.Ngemuva kokuthi ukuguqulwa kwamakhemikhali adingekayo kuqediwe, iqembu elivikelayo lingasuswa kalula, okuvumela ukubuyiselwa kwamaqembu okuqala e-hydroxyl.Kumakhemikhali e-carbohydrate, i-T-butyl-(3R,5S) -6-hydroxy 3,5-O-isopropylidene I-3,5-dihydroxyhexanoate ijwayele ukusetshenziselwa ukuvikela ama-molecule kashukela.Ushukela uqukethe amaqembu amaningi e-hydroxyl angasabela ngama-reagents, okuholela emikhiqizweni engafunwa.Ngokuvikela ngokukhethekile la maqembu e-hydroxyl nge-T-butyl-(3R,5S) -6-hydroxy 3,5-O-isopropylidene 3,5-dihydroxyhexanoate, osokhemisi bangakwazi ukukhohlisa amaqembu e-hydroxyl asele ngaphandle kokuphazanyiswa.Lokhu kuvumela ukuhlanganiswa kokuphuma kokushukela okuyinkimbinkimbi kanye nokucwaninga ukusebenzisana kwe-carbohydrate-protein noma ukuhlanganiswa kwe-glyccoconjugates.Ngaphezu kwalokho, i-T-butyl-(3R,5S) -6-hydroxy 3,5-O-isopropylidene 3,5- Iqembu elivikelayo le-dihydroxyhexanoate livame ukusetshenziswa ngesikhathi sokuhlanganiswa kwemikhiqizo yemvelo, imithi, nezinye izinhlanganisela eziphilayo ezisebenzayo.Ukuvikela kwayo okusebenzayo kanye nezindawo zokuvikela kuvumela osokhemisi ukuthi bafinyelele uhla olubanzi lwama-molecule ahlukene ngokwesakhiwo.Ukuvikelwa kwamaqembu athile e-hydroxyl kusiza ekulawuleni izindlela zokusabela kanye nokufeza i-regioselectivity oyifunayo noma i-stereoselectivity.Ekuphetheni, i-T-butyl-(3R,5S) -6-hydroxy 3,5-O-isopropylidene 3,5-dihydroxyhexanoate inhlanganisela eguquguqukayo esetshenziswa kakhulu kukhemikhali yokwenziwa kwezinto eziphilayo, ikakhulukazi ekuvikelweni nasekuvimbeni kwamaqembu e-hydroxyl.Isakhiwo sayo esiyingqayizivele sivumela ukuvikelwa okukhethiwe, okwenza osokhemisi bakwazi ukulawula ukusabela futhi bathole imikhiqizo efiselekayo.Izicelo zayo zisukela ekuhlanganisweni kwenhlanganisela yezinto eziphilayo eziyinkimbinkimbi kuya kumakhemikhali e-carbohydrate kanye nokukhiqizwa kwemikhiqizo yemvelo kanye nemithi.Ikhono le-compound lokuvikela amaqembu e-hydroxyl ngendlela efanele liwenza ithuluzi eliyigugu ezicini ezihlukahlukene zocwaningo lwamakhemikhali nokuthuthukiswa.