Imikhiqizo

I-Tetrabenzyl Dapagliflozin iyikhemikhali etholakala ku-Dapagliflozin, okuwumuthi odluliselwa ngomlomo okhonjiswe ukwelapha uhlobo 2 lwesifo sikashukela.I-Tetrabenzyl I-Dapagliflozin iphuma ku-Dapagliflozin futhi ibonise amandla okuthuthukisa imiphumela yayo yokwelapha.I-Dapagliflozin iyi-sodium-glucose cotransporter 2 (SGLT2) inhibitor esebenza ngokuvimbela ukumuncwa kabusha kwe-glucose ezinso, okuholela ekwehliseni ukwehla koshukela womchamo kanye nokuphuma ngokuphelele emazingeni eglucose yegazi.Ngokuyinhloko isetshenziselwa ukuthuthukisa ukulawulwa kwe-glycemic ezigulini ezinesifo sikashukela sohlobo 2. I-Tetrabenzyl Dapagliflozin, njenge-derivative ye-Dapagliflozin, iye yathuthukiswa ukuze ithuthukise izakhiwo ze-pharmacokinetic kanye nempumelelo ye-compound yokuqala.Ibonisa izindlela zokusebenza ezifanayo, ezivimbela i-SGLT2 ezinsweni, kodwa ngokuguqulwa okuthile esakhiweni sayo samangqamuzana.Enye inzuzo engaba khona ye-Tetrabenzyl Dapagliflozin kune-Dapagliflozin ukuqina kwayo okukhulayo nokuncibilika.Ukwengezwa kwamaqembu e-benzyl esakhiweni kuthuthukisa izakhiwo zayo zomzimba, kuyenze izinze futhi inyibilike ezindaweni ezahlukene.Lokhu kuncibilika okuthuthukisiwe kungathuthukisa ukumuncwa kanye ne-bioavailability yomuthi emzimbeni.Ngaphezu kwalokho, i-Tetrabenzyl Dapagliflozin ingase ibe nesikhathi eside sokusebenza uma iqhathaniswa ne-Dapagliflozin.Ukuguqulwa kwesakhiwo sayo kungase kubambezele i-metabolism kanye nokuqedwa, okuholela kumthelela oqhubekayo kumazinga e-glucose yegazi.Lesi senzo sesikhathi eside singanikeza ukulawulwa okungcono kwe-glycemic futhi sinciphise imvamisa ye-dosing.I-Tetrabenzyl Dapagliflozin isesigabeni sokuqala socwaningo nokuthuthuka, futhi ucwaningo olwengeziwe luyadingeka ukuze kuqondwe ngokugcwele izinzuzo zayo zokwelapha ezingaba khona.I-compound ikhombisa isithembiso njengokuthuthuka okungaba khona kune-Dapagliflozin, kodwa kuyadingeka uphenyo olwengeziwe ukuze kuhlolwe ukusebenza kwayo, ukuphepha, kanye nokusetshenziswa komtholampilo. Kubalulekile ukuqaphela ukuthi ukusetshenziswa kwe-Tetrabenzyl Dapagliflozin nanoma iyiphi inhlanganisela yemithi kufanele ngaso sonke isikhathi kwenziwe ngaphansi kokuqondisa futhi. isiqondiso sochwepheshe bezempilo.Banganikeza ulwazi oludingekayo mayelana nezinkomba zayo, umthamo, imiphumela emibi engaba khona, nokusebenzisana neminye imithi.