I-Tiamulin 98% Cas: 125-65-5
| Inombolo Yekhathalogi | XD91893 |
| Igama Lomkhiqizo | I-Tiamulin 98% |
| I-CAS | 125-65-5 |
| Ifomu le-Molecularla | I-C22H34O5 |
| Isisindo samangqamuzana | 378.5 |
| Imininingwane Yesitoreji | -20°C |
| Ikhodi Yentela Evumelanisiwe | 2918199090 |
Ukucaciswa Komkhiqizo
| Ukubukeka | Impushana emhlophe |
| U-Asay | 99% iminithi |
| Iphoyinti lokuncibilika | 170-1710C |
| i-alpha | I-D24 +20° (c = 3 ku-abs ethanol) |
| Iphuzu elibilayo | 482.8±45.0 °C(Kubikezelwe) |
| ukuminyana | 1.15±0.1 g/cm3(Kubikezelwe) |
| ukuncibilika | I-DMSO:> 10mg/mL (efudumele) |
| pka | 12.91±0.10(Okubikezelwe) |
| umsebenzi optical | [α]/D +30 kuya +40° (c=1; CH2Cl2) |
I-Pleuromutilin iyi-diterpene ekhiqizwa izinhlobo eziningana ze-basidomycete, ikakhulukazi uhlobo lwe-Pleurotus, eyatholwa ngo-1951. I-Pleuromutilin iyimithi elwa namagciwane enamandla futhi ekhetha kakhulu esebenza ngokumelene nohlu lwamagciwane e-Gram positive, engenakho ukumelana nezigaba ezikhona zama-antibiotic ngenxa yendlela yayo eyingqayizivele. wesenzo.I-Pleuromutilin ivimbela ukwakheka kwamaprotheni ngokubophezela kusizinda V se-23S rRNA futhi lokhu kuye kwaholela ekwakhiweni kwama-analogue amaningi okwenziwa njengama-antibiotic esizukulwane esisha, njenge-tiamulin ne-retapamulin.
I-Pleuromutilins efana ne-tiamulin ne-valnemulin sekunesikhathi eside isetshenziswa emithini yezilwane ukwelapha izifo ezingulubeni.Muva nje i-semisynthetic pleuromutilin, i-retapamulin, yethulwe njengendlela yokwelapha izifo ze-Gram-positive kubantu.I-Pleuromutilins ivimbela umsebenzi we-peptidyl transferase we-bacterial 50S ribosomal subunit ngokubophezela kusayithi elingu-A.
