Imikhiqizo

I-Trans-4-Amino-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid iyinhlanganisela yamakhemikhali enemisebenzi ehlukahlukene, ikakhulukazi ekuhlanganiseni kwezinto eziphilayo kanye nocwaningo lwezemithi.Isakhiwo sayo siqukethe indandatho ye-pyrrolidine esikhundleni seqembu le-amino kanye neqembu elivikela i-tert-butoxycarbonyl (Boc) ku-athomu ye-nitrogen.Okunye ukusetshenziswa okuyinhloko kwe-trans-4-Amino-1-(tert-butoxycarbonyl)pyrrolidine-3- i-carboxylic acid iyisivikelo sokwakha ekuhlanganiseni ama-molecule ezinto eziphilayo eziyinkimbinkimbi.Ukuba khona kweqembu le-amino kuvumela ukuguqulwa kwamakhemikhali okuningi, okuhlanganisa ukuhlangana, i-acylation, noma ukuhlanganisa, okuyisisekelo ekwakhiweni kwenhlanganisela ehlukahlukene enezakhiwo ezithile zokwelapha noma zamakhemikhali.Iqembu elivikelayo le-Boc livikela iqembu lama-amino phakathi nalokhu kusabela, livimbele ukusebenzisana okungafunwa noma ukusabela okuseceleni.Ngaphezu kwalokho, i-trans-4-Amino-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid ibaluleke kakhulu ekuhlanganisweni kwe-peptide-based. izidakamizwa.Ama-Peptides amaketanga amafushane ama-amino acid adlala indima ebalulekile ezinqubweni zebhayoloji.Ngokukhetha ukuvikela iqembu le-Boc, inhlanganisela ingasebenza njengebhlokhi yokwakha ye-amino acid ukwakha ukulandelana kwe-peptide.Lokhu kuvumela ukwakhiwa kwezidakamizwa ezisekelwe ku-peptide, ezingakhomba okuhlosiwe kwamangqamuzana, njengama-receptors noma ama-enzyme, futhi kulungise izindlela ezihlukahlukene zezinto eziphilayo.Le mithi ibonise isithembiso ezindaweni ezifana nokwelashwa komdlavuza, ukwelashwa kwe-antimicrobial, kanye nokuphazamiseka kwamahomoni.Ukuguquguquka kwenhlanganisela nakho kudlulela emandleni ayo njengento yokuqala yokuhlanganiswa kwama-molecule amancane anento ephilayo.Ngokukhohlisa amaqembu asebenzayo kanye ne-stereochemistry ye-trans-4-Amino-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid, abacwaningi bangakha ama-analog noma okuphuma kokunye okunezakhiwo zekhemisi ezithuthukisiwe.Lezi zinhlanganisela eziguquliwe zingahlolelwa abantu abangase babe izidakamizwa, zihlolwe ukuthi ziyakwazi yini ukusebenzisana nezinto ezihlosiwe zebhayoloji, noma zifundelwe izakhiwo zazo zemishini.Ngaphezu kwalokho, i-trans-4-Amino-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid can ingasetshenziswa njengenhlanganisela yereferensi ngezinjongo zokuhlaziya.Ukwakheka kwayo okuzinzile kanye nezakhiwo ezinezimpawu ezinhle kuyenza ibe yigugu njengendinganiso yokulawula ikhwalithi ekukhiqizeni imithi, iqinisekisa ukunemba nokwethembeka kwezindlela zokuhlaziya ezisetshenziselwa ukuhlola ubumsulwa namandla enhlanganisela ehlobene.Ekuphetheni, i-trans-4-Amino-1- (tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid iyinhlanganisela eguquguqukayo enokusetshenziswa okubalulekile ekuhlanganiseni kwezinto eziphilayo kanye nocwaningo lwezemithi.Ukwakheka kwayo okufana ne-amino acid neqembu elivikelayo kuyenza ibe isisekelo esibalulekile sokwakha ama-molecule ezinto eziphilayo eziyinkimbinkimbi, okuhlanganisa ama-peptide kanye nalabo abangase bakhethe izidakamizwa.Uphenyo oluqhubekayo mayelana nezakhiwo zalo kanye nokuguqulwa luzoqhubeka nokwandisa ukusetshenziswa kwalo futhi lube neqhaza ekwakhiweni kwama-ejenti anoveli okwelapha.