Imikhiqizo

I-Trifluoromethanesulfonic anhydride, evame ukubizwa ngokuthi i-triflic anhydride noma i-Tf2O, iyi-reagent eguquguqukayo esetshenziswa kabanzi ku-organic synthesis, ikakhulukazi emkhakheni we-synthetic chemistry.Kuyinhlanganisela esebenza kakhulu esebenza izinjongo eziningi ngenxa ye-asidi eqinile namandla okubhekana nokushintshashintsha kwamakhemikhali okuhlukahlukene.Okunye ukusetshenziswa okuyinhloko kwe-triflic anhydride njenge-ejenti yokuqeda amanzi emzimbeni.Isabela ngamandla nge-alcohols, iguqule ibe ama-ether awo ahambisanayo.Lokhu kusabela, okwaziwa nge-Williamson ether synthesis, kuvame ukusetshenziswa ezindaweni zaselabhorethri nasezinqubweni zezimboni ukuze kwakhiwe ama-molecule ayinkimbinkimbi.I-Triflic anhydride iwusizo ikakhulukazi ekuguquleni uphuzo oludakayo oluvinjiwe, okungenzeka lungasabeli kalula namanye ama-reagents, lube ama-ether ngendlela efanele.Ukwengeza, i-triflic anhydride isetshenziswa ekuvikelweni nasekuvimbeni kwamaqembu asebenzayo ku-organic synthesis.Ingasetshenziselwa ukuvikela amaqembu asebenzayo abucayi, afana notshwala nama-amines, ngokwenza ama-triflates azinzile.Lawa ma-triflates angabese evinjwa ngokukhetha ngaphansi kwezimo ezifanele ukuze kuvuselelwe amaqembu asebenzayo afunekayo.Leli su libaluleke kakhulu ekuhlanganiseni kwezinyathelo eziningi, lapho ukuvikelwa kanye nokuvinjelwa kwamaqembu asebenzayo kuyadingeka ukuze kuzuzwe ukusabela okufunayo ngokukhetha.I-Triflic anhydride futhi ithola ukusebenza njenge-catalyst kanye nomgqugquzeli ekuphenduleni okuhlukahlukene.I-asidi yayo ephezulu, etholakala ku-trifluoromethanesulfonic acid eyikhiqizayo lapho kukhona amanzi, yenza kube lula ukusabela kwe-acid-catalyzed.Ingaphromotha ukuguqulwa okuhlukahlukene okufana nama-esterification, ama-acylation, nokuhlelwa kabusha, okuvumela ukuhlanganiswa kwama-molecule ayinkimbinkimbi.Ngaphezu kwalokho, i-triflic anhydride isetshenziswa njenge-electrophile enamandla ekuphenduleni okuhlukile.Ingasabela nge-nucleophiles ukwethula amaqembu e-triflyl (CF3SO2), asebenza ngezindlela ezihlukahlukene kukhemikhali yokwenziwa.Amaqembu e-Triflyl asebenza njengamaqembu ahamba kahle, avumela ukusabela okulandelayo okufana nokushintshwa kwe-nucleophilic noma ukuhlela kabusha. Naphezu kokusetshenziswa kwayo, i-triflic anhydride kufanele isingathwe ngokuqapha ngenxa yemvelo yayo eyonakalisayo kanye nokusebenza kabusha okungaba khona.Kumelwe kuthathwe izinyathelo ezifanele zokuphepha, kuhlanganise nokusetshenziswa kwezingubo zokuzivikela ezifanele, amagilavu, nezingubo zamehlo, kanye nokusebenza endaweni enomoya omuhle.Ukwengeza, ngenxa yesimo sayo sokugqwala, kuyanconywa ukuthi uphathe i-triflic anhydride ngaphansi kwe-inert atmosphere. amaqembu, i-catalyst, umgqugquzeli, kanye ne-electrophile.Ukuguquguquka kwayo kanye nokusebenza kabusha kuyenza ibe yingxenye ebalulekile yezinqubo eziningi zaselabhorethri nezinqubo zezimboni, okuvumela ukuhlanganiswa okuphumelelayo kwezinhlanganisela ezihlukahlukene zezinto eziphilayo.Kodwa-ke, ukuqapha kufanele kusetshenziswe lapho uphatha i-triflic anhydride, kulandelwa izimiso ezifanele zokuphepha ukuze kuqinisekiswe inhlalakahle kasokhemisi futhi kuvinjwe izingozi elabhorethri.