Imikhiqizo

1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine -3-carboxylic acid ethyl ester iyinhlanganisela yamakhemikhali eyinkimbinkimbi eye yabonisa amandla ezindaweni ezihlukahlukene zamakhemikhali emithi kanye nokutholakala kwezidakamizwa.Nansi incazelo yokusetshenziswa kwayo emagameni angaba ngu-300. Le nhlanganisela, evame ukubizwa ngokuthi i-ethyl ester derivative ye-1-(4-Methoxyphenyl) -7-oxo-6-[4-(2-oxopiperidin-1-yl) phenyl] -4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid, ingeyesigaba se-pyrazolo[3,4-c] pyridine derivatives.Lezi ziphuma zihehe ukutholakala kwezidakamizwa ngenxa yamandla azo ezindaweni ezihlukahlukene zokwelapha.Okunye okungase kube khona ukusetshenziswa kwalesi sithako kulele emkhakheni wocwaningo lokulwa nomdlavuza.I-Pyrazolo[3,4-c] pyridine derivatives ibonise umsebenzi othembisayo wokulwa nokwanda ngokumelene nezinhlobo eziningana zamangqamuzana omdlavuza.Ikhono labo lokuvimbela izindlela ezithile ezihilelekile ekukhuleni kwesimila nokuphila kubenza bakwazi ukwakhiwa kwemithi elwa nomdlavuza.Ucwaningo olwengeziwe luyadingeka ukuhlola indlela yokusebenza nokuhlola ukusebenza kwe-compound kuzilungiselelo zangaphambi komtholampilo kanye nezomtholampilo.Ngaphezu kwalokho, le nhlanganisela ibonise isithembiso njenge-ejenti ye-antibacterial engase ibe khona.Ibonise umsebenzi ngokumelene nezinhlobo ezihlukahlukene zamagciwane, okuhlanganisa kokubili amagciwane e-Gram-positive kanye ne-Gram-negative.Ikhono lokukhomba izinhlobo eziningi liphakamisa amandla ayo ekulweni namagciwane amelana nemithi, asephenduke ukukhathazeka kwezempilo okubalulekile emhlabeni jikelele.Ucwaningo olwengeziwe luqinisekisiwe ukuphenya indlela yalo yesenzo futhi luhlole ukuphumelela kwalo ekulweni nezifo ezibangelwa amagciwane.Ukwengeza, okuphuma ku-pyrazolo[3,4-c] pyridine, okuhlanganisa le nhlanganisela, kubonise amandla ekwelapheni izifo ezivuthayo kanye ne-autoimmune.Ukuvuvukala kudlala indima ebalulekile ezimeni ezihlukahlukene ezifana ne-rheumatoid arthritis kanye ne-psoriasis.Lezi ziphuma zibonise izakhiwo zokulwa nokuvuvukala ngokumodela izindlela ezithile ezihilelekile ekuphenduleni kokuvuvukala.Lokhu kuphakamisa amandla abo njengama-agent okwelapha okuphatha ukuvuvukala okungapheli kanye nezifo ezihambisanayo.Ngaphezu kwalokho, le nhlanganisela ibonise umsebenzi ohlelweni lwezinzwa oluphakathi (CNS).Kuye kwaphenywa amandla ayo ezinkingeni zemizwa njengesifo i-Alzheimer kanye nesifo sikaParkinson.I-compound ingashintsha ama-receptors athile nama-enzyme abandakanyeka ekuqhubekeleni phambili kwesifo, okungenzeka anikeze imiphumela ye-neuroprotective.Kodwa-ke, ucwaningo olwengeziwe luyadingeka ukuze uqonde ngokugcwele indlela yokusebenza kwayo futhi uhlole ukusebenza kahle kwayo ekwelapheni lezi zinkinga eziyinkimbinkimbi.Ngokufingqa, i-1-(4-Methoxyphenyl) -7-oxo-6-[4-(2-oxopiperidin-1-) yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester inesithembiso ezindaweni eziningana zokwelapha, okuhlanganisa ukulwa nomdlavuza, i-antibacterial, anti-inflammatory , kanye nokuphazamiseka kwe-CNS.Amandla ayo asemandleni ayo okukhomba izindlela ezithile nama-receptors abandakanyeka kulezi zimo.Kodwa-ke, ucwaningo olwengeziwe nophenyo kuyadingeka ukuze uhlole ngokugcwele amandla ayo, uthuthukise izakhiwo zayo, futhi uhlole ukuphepha nokusebenza kwayo ezimisweni zomtholampilo.