Imikhiqizo

I-S-(+)-Methyl-(2-chlorophenyl)[(2-(2-thienyl)amino] acetate hydrochloride, eyaziwa nangokuthi S-(+)-Clopidogrel, iyinhlanganisela yemithi enefomula yamakhemikhali ye-C16H16ClNO2S·HCl Iphuma ku-chiral ye-clopidogrel, okuwumuthi obalulekile we-antiplatelet. Ukusetshenziswa okuyinhloko kwe-S-(+)-Methyl-(2-chlorophenyl)[(2-(2-thienyl)amino] acetate hydrochloride kuyasebenza isithako ekwakhiweni kwezidakamizwa zenhliziyo, ikakhulukazi ama-antiplatelet agents.Isebenzisa imiphumela yayo yokwelapha ngokuvimbela ukuhlangana kweplatelet, ukuvimbela ukwakheka kwamahlule egazi, nokunciphisa ubungozi bemicimbi yenhliziyo indima ebalulekile ekusebenzeni nasekuhlanganisweni kwamaplatelet Ngokubophezela ngokungenakuhlehliswa kule receptor, i-S-(+)-Methyl-(2-chlorophenyl)[(2-(2-thienyl)amino] i-acetate hydrochloride ivimbela ukusebenza kweplatelet futhi ivimbele ukwakheka. Amahlule egazi Le ndlela yokwenza ikwenza kube umuthi obalulekile wokuvimbela izehlakalo ze-thrombotic ezigulini ezisengozini enkulu, njengalezo ezinomlando we-acute coronary syndrome, ischemic stroke, noma isifo se-peripheral artery.S-(+) -Methyl- (2-chlorophenyl)[(2-(2-thienyl)amino] i-acetate hydrochloride ivamise ukunikezwa ngomlomo ngendlela yamaphilisi noma amaphilisi.Ngemuva kokuyiphuza, ishintsha i-metabolic esibindini ukuze ikhiqize i-metabolite yayo esebenzayo.Le metabolite esebenzayo ibophezela ngendlela engenakuhlehliswa ku-P2Y12 receptor, isebenzisa imiphumela yayo ye-antiplatelet isikhathi eside.Inhlanganisela ivamise ukunikezwa kanye ngosuku, kungaba njengokwelapha okuzimele noma kuhlanganiswe neminye imithi ye-antiplatelet, njenge-aspirin.Kubalulekile ukuqaphela ukuthi i-S-(+)-Methyl-(2-chlorophenyl)[(2-(2) -thienyl)amino] i-acetate hydrochloride kufanele isetshenziswe kuphela ngaphansi kokuqondisa kochwepheshe bezempilo, njengoba ukusetshenziswa kwayo kungase kube namandla.