1,1-Cyclobutanedicarboxylatodiammineplatinum (II) Cas:41575-94-4
| Inombolo Yekhathalogi | XD90684 |
| Igama Lomkhiqizo | 1,1-Cyclobutanedicarboxylatodiammineplatinum (II) |
| I-CAS | 41575-94-4 |
| I-Molecular Formula | I-C6H12N2O4Pt |
| Isisindo samangqamuzana | 371.25 |
| Imininingwane Yesitoreji | 2-8°C |
| Ikhodi Yentela Evumelanisiwe | 28439090 |
Ukucaciswa Komkhiqizo
| Ukubukeka | Impushana emhlophe ukuya kokumhlophe |
| Isivivinyo | 99% |
| Amanzi | ≤0.5% |
| Ukulahlekelwa Ekumisweni | ≤0.5% |
| Ama-Chloride | ≤100ppm |
| Izinto Ezihlobene | ≤0.25% |
| Noma Ikuphi Ukungcola Okungashiwongo | ≤ 0.1% |
| Konke okunye ukungcola | ≤0.5% |
| 1,1-Cyclobutanedicarboxylic acid | ≤ 0.5% |
Izidakamizwa ze-antineoplastic zesizukulwane sesibili zeplatinamu.I-antitumor spectrum nomsebenzi we-antitumor uyafana nalowo we-cisplatin, kodwa ukuncibilika kwamanzi kungcono kunokwe-cisplatin, kanti ubuthi ezinso nabo buphansi.Inomphumela omuhle wokwelapha kumdlavuza wamaphaphu amancane, umdlavuza wesibeletho, i-squamous cell carcinoma yekhanda nentamo, isimila samasende, i-malignant lymphoma, njll. Ingasetshenziswa futhi kumdlavuza womlomo wesibeletho, umdlavuza wesinye, njll.
Imithi elwa nomdlavuza ye-platinamu yesizukulwane sesibili inemisebenzi efanayo futhi isetshenziswa njenge-cisplatin.Isebenza kakhulu kune-cisplatin kwamanye amathumba, futhi inamandla kune-cisplatin njenge-radiosensitizer ngaphansi kwezimo ze-hypoxic.Isetshenziselwa ikakhulukazi umdlavuza wesibeletho, umdlavuza wamasende, umdlavuza wamaphaphu omncane kanye nomdlavuza wekhanda nentamo.
I-Carboplatin iyisidakamizwa esilwa nomdlavuza esisekelwe kuplatinamu esilimaza i-DNA ngokwakha ukuhlanganiswa kwe-intrachain nezinsalela ze-guanine eziseduze.Umthelela we-antitumor wale mithi ufezwa ngokulahleka komsebenzi wokulungiswa kwe-DNA okungafani (umgomo wokugomela i-MMR) kanye nokungeniswa kokufa kweseli okuhleliwe.
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