Imikhiqizo

I-2,3-Difluoro-4-ethoxybenzeneboronic acid iyinhlanganisela ethola usizo emikhakheni eminingana yamakhemikhali, ikakhulukazi ku-organic synthesis kanye namakhemikhali okwelapha.Ngesakhiwo sayo esiyingqayizivele kanye nokusebenza kabusha, sekuyisakhiwo esibalulekile sokwakha ama-molecule ezinto eziphilayo eziyinkimbinkimbi nezinhlanganisela zemithi.Okunye kwezicelo ezibalulekile ze-2,3-Difluoro-4-ethoxybenzeneboronic acid ilele ekusetshenzisweni kwayo ekuphenduleni okuhlangene.Ukusabela okuhlanganayo, okufana nokuhlangana kwe-Suzuki-Miyaura kanye ne-Buchwald-Hartwig, kuyindlela enamandla yokwakha amabhondi e-carbon-carbon kanye ne-carbon-heteroatom.Kulokhu kusabela, i-2,3-Difluoro-4-ethoxybenzeneboronic acid ingasebenza njengengxenye ye-boronate ester, isabela ngama-electrophiles ahlukahlukene (isb, i-aryl halides, i-vinyl halides) ngaphansi kwethonya lama-catalysts afanelekile.Lokhu kuvumela ukuhlanganiswa kwezinhlanganisela ezihlukahlukene ezinezakhiwo eziphilayo ezisebenzayo, njengama-ejenti ekhemisi noma amakhemikhali ezolimo.Ngaphezu kwalokho, ukuba khona kwama-athomu e-fluorine ku-2,3-Difluoro-4-ethoxybenzeneboronic acid kungadlulisela izakhiwo ezinenzuzo kuma-molecule avelayo.Ukufaka esikhundleni se-fluorine kungathuthukisa ukuzinza, i-lipophilicity, kanye nephrofayili ye-pharmacokinetic yezinhlanganisela eziphilayo, kubenze babe abamele izidakamizwa abaphumelelayo.Ngakho-ke, ukusetshenziswa kwamasu kwe-2,3-Difluoro-4-ethoxybenzeneboronic acid njengesandulela ekuhlanganisweni kwezinhlanganisela ezifana nezidakamizwa kunganikeza ukufinyelela kuma-molecule ane-fluorinated ngomsebenzi othuthukisiwe wezinto eziphilayo kanye nezakhiwo ze-physicochemical ezifiselekayo. Ngaphezu kwalokho, iqembu le-ethoxy elikhona ku-2 ,3-Difluoro-4-ethoxybenzeneboronic acid inikeza ukuguquguquka okwengeziwe ezinhlelweni zokwenziwa.Kungaba ngaphansi kokusabela kwe-nucleophilic substitution, okuvumela ukwethulwa kwamaqembu ahlukahlukene asebenzayo endaweni ye-ethoxy.Lokhu kuvumela ukukhishwa kwenhlanganisela ukuze kulungiselelwe izakhiwo zayo ngokwezinjongo ezithile noma ukwethula amaphuzu engeziwe okuhlukahluka kokuhlanganiswa komtapo wolwazi ukuze kutholwe izidakamizwa. amakhemikhali emithi.Ukubamba kwayo iqhaza ekuphenduleni kokuhlangana, ukufakwa kwama-athomu e-fluorine, kanye nokuphuma kokunye endaweni ye-ethoxy kuyenza ibe ithuluzi elibalulekile ekwakheni izinhlanganisela ezihlukahlukene ze-organic nezinhlelo zokusebenza zemithi ezingase zibe khona.Ukusetshenziswa kwayo kuvumela ukuhlanganiswa kwama-molecule ayinkimbinkimbi nemitapo yolwazi ukuze kutholwe izidakamizwa futhi kunikeza ukufinyelela kumakhompiyutha ane-fluorinated anezakhiwo ezithuthukisiwe.