Imikhiqizo

Inhlanganisela (2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-ethoxybenzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate iyingqamuzana ye-organic eyinkimbinkimbi engase isetshenziswe ezindaweni eziningana zamakhemikhali kanye nocwaningo lwezemithi.Okunye okungase kusetshenziswe lesi sakhi ku-organic synthesis.Ukuba khona kwamaqembu amaningi asebenzayo, kufaka phakathi i-acetoxymethyl, i-chloro, ne-ethoxybenzyl, kunikeza izindlela ezahlukahlukene zokukhohlisa nokuguqula i-molecule.Osokhemikhali bangasebenzisa le nhlanganisela njengento yokuqala ukuze bahlanganise izinhlanganisela eziphilayo eziyinkimbinkimbi, ezifana nezimaphakathi zemithi noma okuphuma kokunye komkhiqizo wemvelo.Ngokukhetha ngobuchule futhi balungise amaqembu athile asebenzayo, abacwaningi bangakwazi ukuhlanganisa izici zenhlanganisela futhi bathuthukise izici zayo ezifiselekayo, ezifana nomsebenzi webhayoloji noma ukunyibilika.Okunye okungase kube khona ukusetshenziswa kwe-(2R,3R,4R,5S,6S) -2-(acetoxymethyl)- I-6-(4-chloro-3-(4-ethoxybenzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate ilele kukhemikhali yezokwelapha.Isakhiwo senhlanganisela siqukethe izici ezimbalwa ezivame ukutholakala kuma-molecule asebenza ngokwemithi, njengendandatho yepyran kanye neqembu le-benzyl elinuka kamnandi.Abacwaningi bezemithi bangahlola amandla ekhemisi ale ngxube ngokutadisha ukusebenzisana kwayo nezinto ezihlosiwe zebhayoloji, benze izifundo zobudlelwano bomsebenzi wesakhiwo, kanye nokuhlola ukusebenza kahle kwayo kokwelapha.Ukuba khona kweqembu le-triacetate kungase futhi kunikeze izinzuzo ezengeziwe, njengokuzinza okuthuthukisiwe, ukwanda kwe-lipophilicity, noma ukuqina kolwelwesi olunwetshiwe, okuyizinto ezifiselekayo ekuthuthukisweni kwezidakamizwa.Ngaphezu kwalokho, i-stereochemistry eyingqayizivele yenhlanganisela (2R,3R,4R,5S,6S) inikela emandleni ayo njenge-chiral building block in asymmetric synthesis.Izikhungo ze-chiral ezikhona ku-molecule zinikeza ithuba lokulungiswa kwezinhlanganisela ezihlanzekile ze-enantiomerically, ezibalulekile ekukhiqizweni kwemithi kanye namakhemikhali ezolimo.Osokhemisi bezinto eziphilayo bangasebenzisa le nhlanganisela njengento yokuqala ye-chiral noma bayethule endleleni eyinkimbinkimbi yokuhlanganisa ukuze bathole imikhiqizo ehlanzekile enantiomerically.Kubalulekile ukuqaphela ukuthi ukusebenza nale nhlanganisela kudinga ubuchwepheshe ekuphatheni nasekuhlanganiseni ama-molecule e-organic ayinkimbinkimbi.Abacwaningi kufanele bathathe izinyathelo zokuphepha ezifanele futhi baqinisekise ubumsulwa benhlanganisela kanye nezimpawu ngaphambi kokusetshenziswa. Kafushane, (2R,3R,4R,5S,6S) -2-(acetoxymethyl)-6-(4-chloro-3-(4-ethoxybenzyl) ) i-phenyl) i-tetrahydro-2H-pyran-3,4,5-triyl triacetate inesithembiso njengenhlanganisela eguquguqukayo ku-organic synthesis, ikhemikhali yezokwelapha, kanye nokuhlanganiswa kwe-asymmetric.Ngamaqembu ayo amaningi asebenzayo kanye ne-stereochemistry ehlukile, inikeza amathuba okuthuthukiswa kwezinhlanganisela zenoveli ezinokusetshenziswa okungenzeka emikhakheni eyahlukene yesayensi, okuhlanganisa ukutholakala kwezidakamizwa, isayensi yezinto ezibonakalayo, kanye nesayensi yezinto eziphilayo.