Imikhiqizo

(2S,5S)-5-(((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1 -hi]i-indole-2-carboxylic acid, asibhekisele kuyo njenge-Compound X, i-molecule eyinkimbinkimbi engase isetshenziswe emkhakheni wamakhemikhali okwelapha nokutholwa kwezidakamizwa.Isakhiwo sayo esiyingqayizivele sihlanganisa i-azepine, indole, ne-fluorene moieties, enikeza amathuba emisebenzi ehlukahlukene yezinto eziphilayo kanye nezicelo zokwelapha.I-Compound X inamaqembu amaningana asebenzayo, okuhlanganisa iqembu le-carbonyl neqembu le-amide.Lawa maqembu anika amandla ukusebenzisana okungaba khona nokuhlosiwe kwebhayoloji.Inhlanganisela ingaba yisiqalo sokuhlanganiswa kanye nokwenza kahle kwezinhlanganisela zomthofu ezinhlelweni zokutholwa kwezidakamizwa.Okunye okungase kube khona kweCompound X kusezicini zayo zokulwa namagciwane.Ukuba khona kweqembu le-fluorene, elaziwa ngomsebenzi walo wokulwa namagciwane, kusikisela ukuthi le nhlanganisela ingase ivimbele ukukhula kwezinambuzane ezihlukahlukene ezibangela izifo ezifana namagciwane, isikhunta, noma izinambuzane.Ngokulungisa ukwakheka kwe-Compound X, ososayensi bangakwazi ukulungisa kahle izici zayo zokulwa namagciwane futhi bathuthukise ukukhetha kwayo ngokumelene namagciwane athile.Ngaphezu kwalokho, isakhiwo esiyingqayizivele se-Compound X singase siyenze ibe ikhandidethi elinamandla lokuthuthukiswa kwezidakamizwa ezilwa nomdlavuza.Amakhompiyutha asekelwe e-Indole abonise umsebenzi omelene nezinhlobo ezihlukahlukene zomdlavuza, osebenza njengama-inhibitors wezindlela ezithile zokubonisa ezihilelekile ekwandeni kwamangqamuzana omdlavuza kanye nokusinda.Ukwengezwa kwe-azepine ne-fluorene moieties ku-Compound X kungathuthukisa ukusebenza kwayo nokukhetha njenge-ejenti elwa nomdlavuza.Abacwaningi bangahlola amandla e-Compound X njengenhlanganisela eholayo futhi bathuthukise okuphuma kokunye okubonisa umsebenzi othuthukisiwe wokulwa nomdlavuza kanye nobuthi obuncishisiwe.Ukwengeza, i-Compound X ingase iphenywe amandla ayo njenge-ejenti ye-neuroprotective.I-fluorene ne-azepine moieties ibonise izakhiwo ze-neuroprotective ocwaningweni lwangaphambilini.Ukwakheka kwale nhlanganisela kuyenza ibe ikhandidethi elithakaselekayo lokuhlola okwengeziwe ekwelapheni izifo ze-neurodegenerative, njenge-Alzheimer's noma i-Parkinson's.Ngokuqonda izindlela zokwenza kanye nokuguqula i-Compound X ngokufanele, abacwaningi bangakwazi ukuthuthukisa ukungenelela kokwelapha ukuvimbela noma ukunciphisa ukuqhubeka kwalezi zifo ezithena amandla. -yl)methoxy)carbonyl)amino)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indole-2-carboxylic acid, noma iCompound X, inamandla amakhulu emkhakheni wamakhemikhali emithi kanye nokutholakala kwezidakamizwa.Isakhiwo sayo samangqamuzana esiyingqayizivele sinikeza amathuba okuthuthukiswa kwama-antimicrobial agents, izidakamizwa ezilwa nomdlavuza, kanye nezinhlanganisela ze-neuroprotective.Ucwaningo olwengeziwe, ukuguqulwa, kanye nokwenza kahle kweCompound X kungadalula amandla ayo aphelele okwelapha, okuholela ekuthuthukisweni kwemithi emisha yokwelapha izifo ezihlukahlukene.