Imikhiqizo

I-3-tert-Butoxycarbonylphenylboronic acid, eyaziwa nangokuthi i-Boc-phenylboronic acid, iyingxenye ebalulekile ye-boronic acid enezinhlelo zokusebenza ezibalulekile ku-organic synthesis kanye namakhemikhali emithi.Okunye ukusetshenziswa okuyinhloko kwe-3-tert-Butoxycarbonylphenylboronic acid iyiqembu elivikelayo ku-organic ukuhlanganisa.Iqembu le-tert-butyloxycarbonyl (BOC) livamise ukuqashwa ukuze livikele okwesikhashana amaqembu asebenzayo e-amine ngesikhathi sokusabela okuhlukahlukene.Ngokunamathisela iqembu le-BOC ku-amine moiety, ukusebenza kabusha kwe-amine kuncishisiwe, okuvumela ukusabela okukhethiwe kwezinye izikhundla ku-molecule.Iqembu le-BOC lingasuswa kalula ngaphansi kwezimo ezithambile, ngaleyo ndlela liveze ukusebenza kwe-amine yasekuqaleni.Lelisu leqembu elivikelayo lenza ukuhlanganiswa okuphumelelayo kwama-molecule ezinto eziphilayo eziyinkimbinkimbi, njengemithi nemikhiqizo yemvelo.Ngaphezu kwalokho, i-3-tert-Butoxycarbonylphenylboronic acid isebenza njenge-reagent ebalulekile yokwakhiwa kwebhondi ye-carbon-carbon.Ama-asidi e-Boronic, okuhlanganisa ne-Boc-phenylboronic acid, enza kalula ama-boronate esters lapho esabela ngama-nucleophile, afana notshwala noma ama-amine.Lawa ma-boronate ester angabese enza izinguquko ezihlukahlukene, okuhlanganisa ukusabela kokuhlangana kwe-Suzuki-Miyaura, ukuhlanganisa kwe-Negishi, kanye nama-Stille couplings.Lokhu kusabela kuvumela ukwakheka kwama-molecule ezinto eziphilayo eziyinkimbinkimbi anamaphethini ahlukahlukene afaka esikhundleni namaqembu asebenzayo.I-Boc-phenylboronic acid iwusizo kakhulu ekwethuleni i-phenylboronic acid moiety kuma-molecule aqondiwe. Ngaphezu kwalokho, i-Boc-phenylboronic acid idlala indima ebalulekile kukhemikhali yezokwelapha.Umsebenzi we-boronic acid ungahlanganyela ngokukhetha nama-dioli noma amaqembu asebenzayo azwela i-ester kokuhlosiwe kwebhayoloji, okuvumela ukuklanywa kwe-boronate-based enzyme inhibitors kanye nama-receptor ligands.I-Boc-phenylboronic acid ingafakwa kuma-molecule amancane, ama-peptide, noma ama-prodrugs ukuze kudluliselwe izici ezifiselekayo noma ukuthuthukisa ukucaciswa okuqondisiwe.Lezi zinhlanganisela ezisekelwe e-boronate zibonise isithembiso ekwelapheni izifo ezihlukahlukene, kuhlanganise nomdlavuza, isifo sikashukela, nokuvuvukala.Ngokufingqa, i-3-tert-Butoxycarbonylphenylboronic acid, noma i-Boc-phenylboronic acid, ithola ukusetshenziswa okuhlukahlukene ekuhlanganiseni kwe-organic kanye namakhemikhali emithi.Iqembu layo le-BOC lisebenza njengeqembu elivikelayo, elivumela ukusabela okukhethiwe kwezinye izikhundla ku-molecule.Ngaphezu kwalokho, ukusebenza kwe-boronic acid kwenza ukwakheka kwe-carbon-carbon bond, kube lula ukuhlanganiswa kwama-molecule e-organic eyinkimbinkimbi.Ukwengeza, i-Boc-phenylboronic acid idlala indima ebalulekile kukhemikhali yezokwelapha, lapho isetshenziswa ekwakhiweni kwe-boronate-based enzyme inhibitors kanye nama-receptor ligands.Sekukonke, i-Boc-phenylboronic acid iyi-reagent ebalulekile enomthelela ekuthuthukisweni kwamakhemikhali okwenziwa kanye nocwaningo lokutholwa kwezidakamizwa.