(2S,3R,4S,5S,6R)-2-(3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)-4-chlorophenyl)-tetrahydro-6-(hydroxymethyl)-2-methoxy -2H-pyran-3,4,5-triol CAS: 1279691-36-9
| Inombolo Yekhathalogi | XD93372 |
| Igama Lomkhiqizo | (2S,3R,4S,5S,6R)-2-(3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)-4-chlorophenyl)-tetrahydro-6-(hydroxymethyl)-2-methoxy -2H-pyran-3,4,5-triol |
| I-CAS | 1279691-36-9 |
| Ifomu le-Molecularla | I-C24H29ClO8 |
| Isisindo samangqamuzana | 480.94 |
| Imininingwane Yesitoreji | I-ambient |
Ukucaciswa Komkhiqizo
| Ukubukeka | Impushana emhlophe |
| U-Asay | 99% iminithi |
Inhlanganisela (2S,3R,4S,5S,6R)-2-(3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)-4-chlorophenyl)-tetrahydro-6-(hydroxymethyl)-2 I-methoxy-2H-pyran-3,4,5-triol iyi-molecule eyinkimbinkimbi engase isetshenziswe emikhakheni ehlukahlukene, kuhlanganise namakhemikhali emithi nemithi.Inhlanganisela ingeyesigaba se-pyranopyrans, okuyizinhlanganisela ze-cyclic eziqukethe indandatho yepyran ehlanganisiwe. ngenye indandatho ye-pyran.Ukuba khona kwama-stereocenters amaningi esakhiweni sawo kuyenza ibe i-molecule ye-chiral, okusho ukuthi ikhona ngezindlela ezimbili ze-enantiomeric ezingaba nemisebenzi ehlukene yezinto eziphilayo.Okunye okungase kube khona ukusetshenziswa kwalesi sakhi ukutholakala kwezidakamizwa nokuthuthuka.Izici zesakhiwo se-molecule, njengamaqembu e-benzyl ne-chlorophenyl, kuhlanganiswe nokuba khona kwamaqembu amaningi e-hydroxyl, aphakamisa ukuthi ingabonisa umsebenzi webhayoloji.Osokhemikhali bemithi bangahlola amandla ekhemikhali njengenhlanganisela eholayo ekuthuthukisweni kwemithi emisha, ikakhulukazi lezo eziqondiswe ezifweni ezihlanganisa i-carbohydrate metabolism.Ukuba khona kweqembu (S) -tetrahydrofuran-3-yloxy kuphakamisa ukuthi inhlanganisela ingase ibe nekhono lokusebenzisana. nama-receptors noma ama-enzyme abandakanyeka ku-carbohydrate metabolism noma izindlela zokubonisa.Abacwaningi bangaphenya amandla ayo njenge-inhibitor noma i-modulator yama-enzyme athile noma ama-receptors abandakanyeka kulezi zinqubo.Ukwengeza, inkimbinkimbi yesakhiwo se-compound ingase iyenze ibe ikhandidethi elifanelekile lokuthuthukiswa kwamakhemikhali emithi ngokusebenzisa ukuguqulwa kwesakhiwo.Ngaphezu kwalokho, i-scaffold ye-pyranopyran ye-compound iqukethe amaqembu amaningi e-hydroxyl, okungamaqembu abalulekile asebenzayo ekwakhiweni kwezidakamizwa.Amaqembu e-Hydroxyl angabamba iqhaza ekusebenzisaneni kwe-hydrogen bonding, okunomthelela ekuncibilikeni kwe-compound, ukuzinza, kanye nezakhiwo ze-pharmacokinetic.Osokhemisi bezokwelapha bangasebenzisa lawa maqembu ukuze bathuthukise amandla enhlanganisela, ukukhetha, kanye nezinye izici zekhemisi.Isakhiwo esiyinkimbinkimbi se-compound siphakamisa futhi ukusetshenziswa okungenzeka kusayensi yezinto zokwakha kanye nokuhlanganiswa kwezinto eziphilayo.Ukuhlelwa kwayo okuyingqayizivele kwamaqembu asebenzayo kungase kusetshenziselwe ukuhlanganiswa kwenoveli yenhlanganisela yezinto eziphilayo ezinezakhiwo ezithile noma imisebenzi ethile.Ukwengeza, i-compound ingase ibe isiqalo sokwakhiwa kwezinto ezintsha, njengama-polymers noma izakhiwo ze-supramolecular, ezingasetshenziswa ezimbonini ezihlukahlukene. (3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)-4-chlorophenyl)-tetrahydro-6-(hydroxymethyl)-2-methoxy-2H-pyran-3,4,5-triol inesakhiwo izici ezenza isebenziseke kakhulu kukhemistri yezemithi neyezokwelapha, isayensi yezinto zokwakha, kanye nokuhlanganiswa kwezinto eziphilayo.Isakhiwo sayo esiyinkimbinkimbi nohlu oluhlukene lwamaqembu asebenzayo lunikeza amathuba okuhlola ekutholweni kwezidakamizwa, ukuguqulwa kwama-enzyme, ukuthuthukiswa kwezinto, nezinye izindawo zocwaningo.
