Imikhiqizo

I-2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone (TMS-D-glucose lactone) iyinhlanganisela yamakhemikhali eyaziwa ngokusebenza kwayo ku-organic synthesis, ikakhulukazi emkhakheni we-carbohydrate chemistry.Iphuma ku-D-glucose, ushukela ovela ngokwemvelo, futhi inezinto eziyingqayizivele eziyenza isebenziseke ekuphenduleni kwamakhemikhali okuhlukahlukene.Okunye ukusetshenziswa okuyinhloko kwe-TMS-D-glucose lactone iyiqembu elivikelayo kumakhemikhali ama-carbohydrate.Ama-carbohydrate, kuhlanganise noshukela, angaba namaqembu amaningi e-hydroxyl, angasabela namanye ama-reagents noma enze izinguquko ezingafuneki ngesikhathi sokuhlanganiswa.Ngokuvikela ngokukhethekile amaqembu athile e-hydroxyl esebenzisa i-TMS-D-glucose lactone, osokhemisi bangakwazi ukulawula imiphumela yokusabela futhi basebenzise izakhiwo zama-carbohydrate ngempumelelo kakhulu.Ngemuva kokuthi ukusabela okufunayo sekuqediwe, amaqembu avikelayo angasuswa kalula, aveze umkhiqizo owufunayo.I-TMS-D-glucose lactone iphinde ithole izinhlelo zokusebenza njengento ephakathi ekuhlanganiseni kokuphuma kokunye okuyinkimbinkimbi kwe-carbohydrate.Ngokukhetha ngokukhetha amaqembu e-hydroxyl e-TMS-D-glucose lactone, osokhemisi bangakwazi ukwethula inqwaba yamaqembu asebenzayo noma ezinye izinto ezifakwa esikhundleni ku-molecule ye-carbohydrate.Lokhu kuvumela ukwakhiwa kwenhlanganisela ye-carbohydrate ehlukahlukene enezinhlelo zokusebenza ezingase zibe khona kwezemithi, izimonyo, nesayensi yezinto zokwakha.Ngaphezu kwalokho, i-TMS-D-glucose lactone isetshenziswa ekuhlanganiseni kwabanikela nge-glycosyl ukuze kutholakale ukusabela kwe-glycosylation.I-Glycosylation iyisinyathelo esibalulekile ekwakhiweni kwezibopho ze-glycosidic, ezibalulekile ekwakhiweni kwama-carbohydrate nama-glycojugates.I-TMS-D-glucose lactone ingaguqulwa ibe abanikeli be-glycosyl, esebenza njengezihlanganisi ezisebenzayo ekuphenduleni kwe-glycosylation, okuvumela ukunamathiselwa kwama-carbohydrates kwamanye ama-molecule.Ngaphezu kwalokho, i-TMS-D-glucose lactone isetshenziswa ekukhiqizeni ama-polymers asekelwe ku-carbohydrate.Ngokufaka i-TMS-D-glucose lactone ekuphenduleni kwe-polymerization, osokhemisi bangakha amaketanga e-polymer noma amanethiwekhi anama-carbohydrate backbones.Lawa ma-carbohydrate polymers angaba nezinto eziyingqayizivele futhi angathola izinhlelo zokusebenza ezindaweni ezifana nezinhlelo zokulethwa kwezidakamizwa, i-bioengineering, kanye ne-biomaterials.Kuyaphawuleka ukuthi i-TMS-D-glucose lactone kufanele iphathwe ngokucophelela ngenxa yomswakama wayo nokuzwela komoya.Ngokuvamile igcinwa futhi iphathwe ngaphansi kwe-nitrogen noma i-argon atmospheres ukuvimbela ukuwohloka.Kafushane, i-2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone (TMS-D-glucose lactone) iyinhlanganisela eguquguqukayo esetshenziswa kakhulu ukwakheka kwe-carbohydrate.Izicelo zayo eziyinhloko zihlanganisa ukuvikela amakhemikhali eqembu, ukuhlanganiswa okuphakathi, ukwakheka komnikezeli we-glycosyl, nokukhiqizwa kwama-polymers asekelwe ku-carbohydrate.Ngokusebenzisa i-TMS-D-glucose lactone kulezi zinqubo, osokhemisi bangakwazi ukulawula kangcono ukusabela kwe-carbohydrate futhi bakhe okuphuma kokunye okuhlukile kwe-carbohydrate ngokusetshenziswa okungenzeka emikhakheni eyahlukene.