![3,3′,5,5′-Tetramethyl-[1,1'-biphenyl]-4,4′-diamine Cas:54827-17-7 99% Isithombe Esifakiwe](http://cdn.globalso.com/xdbiochems/54827-17-71.jpg)
3,3′,5,5′-Tetramethyl-[1,1'-biphenyl]-4,4′-diamine Cas:54827-17-7 99%
| Inombolo Yekhathalogi | XD90518 |
| Igama Lomkhiqizo | 3,3',5,5'-Tetramethyl-[1,1'-biphenyl]-4,4'-diamine |
| I-CAS | 54827-17-7 |
| I-Molecular Formula | I-C16H20N2 |
| Isisindo samangqamuzana | 240.34 |
| Imininingwane Yesitoreji | 2 kuya ku-8 °C |
| Ikhodi Yentela Evumelanisiwe | 29215990 |
Ukucaciswa Komkhiqizo
| Ukubukeka | Okumhlophe, okumhlophe kuya kokumpunga noma okuphuzi |
| Isivivinyo | >99% |
| Ukulahlekelwa Ekumisweni | <2.0% |
| Okokusetshenziswa kocwaningo kuphela, hhayi okomuntu | ukusetshenziswa kocwaningo kuphela, hhayi ukusetshenziswa komuntu |
Ubuthi be-Ricin (RT) buwubuthi obubulalayo besibili owaziwayo;iqokwe yi-CDC njenge-ejenti ekhethiwe.I-RT yenziwa isitshalo sikabhontshisi;amathani alinganiselwa ku-50,000 e-RT akhiqizwa minyaka yonke njengomkhiqizo kawoyela we-castor.I-RT inama-subunits amabili, iketango le-ribotoxic A (RTA) kanye neketango B elibopha i-galactose (RTB).I-RT ibophezela kuwo wonke amaseli ezilwane ezincelisayo futhi uma isifakwe ngaphakathi, i-RTA eyodwa yenza kusebenze wonke ama-ribosome kuseli.Ilawulwa njenge-aerosol, i-RT idala umonakalo osheshayo wamaphaphu kanye ne-fibrosis elandelwa ukufa.Ayikho imithi yokugoma egunyazwe yi-Food and Drug Administration futhi ukwelashwa kusebenza kuphela emahoreni ambalwa okuqala ngemva kokuchayeka.Senze umuthi wokugomela osetshenziswa kabusha we-RTA onokuguquka okubili kwe-V76M/Y80A (RiVax).Iphrotheni ivezwa ku-Escherichia coli futhi ayinabo ubuthi futhi ayivimbeli umzimba kumagundane, onogwaja, nakubantu.Uma amagundane agonyiwe ephonselwa inselelo nge-RT ejovwe, efakwe umoya omncane, noma elawulwa ngomlomo (egavaged), avikelwa ngokuphelele.Manje sesenze ukwakheka kwe-RiVax okushisayo, okune-aluminium-adjuvant futhi sikuhlole kuma-rhesus macaques.Ngemva kwemijovo emithathu, izilwane zakha amasosha omzimba ayezivikela ngokuphelele kumthamo obulalayo we-RT ene-aerosolized.Lawa ma-antibody enza i-RT angabi namandla futhi aqhudelana ngamadigri ahlukahlukene ngephaneli yokungathathi hlangothi nokungangenisi amasosha omzimba egundane elilodwa elaziwa ngokubona ama-epitopes athile ku-RTA yomdabu.Iphrofayili yokuncintisana yama-antibody ewumphumela ingase imele isiginesha yokuvikelwa kwamasosha omzimba.Okubalulekile, isiginesha efanayo yabonwa kusetshenziswa i-sera evela kubantu abagonywe yi-RiVax.
