Imikhiqizo

I-Acetoxy Empagliflozin, eyaziwa nangokuthi i-empagliflozin acetate, iwuhlobo olushintshiwe lomuthi we-antidiabetic empagliflozin.I-Empagliflozin ingeyesigaba sezidakamizwa ezaziwa ngokuthi i-sodium-glucose co-transporter 2 (SGLT2) inhibitors, esetshenziselwa ngokuyinhloko ukuphatha uhlobo 2 lwesifo sikashukela. I-Empagliflozin isebenza ngokuvimbela i-SGLT2, iphrotheni enesibopho sokumunca kabusha ushukela ezinso.Ngokuvimbela le phrotheni, (3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy) -6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one iyinhlanganisela yamakhemikhali eyinkimbinkimbi ene igama lekhemikhali elide.Ingena ngaphansi kwesigaba se-triMethylsilyloxy pyranones, esetshenziswa kakhulu ezinhlelweni ezehlukene zesayensi nezimboni.Okunye ukusetshenziswa okubalulekile kwe-(3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy) -6-( (i-triMethylsilyloxy)Methyl)i-tetrahydro-2H-pyran-2-one iyiqembu elivikelayo ku-organic synthesis.Amaqembu okuvikela angamaqembu asebenzayo esikhashana asetshenziselwa ukuvikela amasayithi athile asebenzayo ku-molecule ngesikhathi sokusabela kwamakhemikhali.Esimeni se-(3R,4S,5R,6R)-3,4,5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one, amaqembu e-triMethylsilyloxy asebenza njengezingxenye ezivikelayo. .Ngesikhathi sokusabela, lawa maqembu avikela amaqembu athile asebenzayo ekubhekaneni nokusabela okungafuneki, okuvumela ukusabela okufunayo ukuthi kuqhubeke kahle.Ngemva kokuqeda ukusabela, amaqembu e-triMethylsilyloxy angasuswa kalula, aveze amaqembu asebenzayo okuqala.Okunye ukusetshenziswa kwe-(3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy) -6-((triMethylsilyloxy) I-Methyl) i-tetrahydro-2H-pyran-2-one iku-synthesis ye-organic compounds.Ingasetshenziswa njengebhlokhi yokwakha ukwakha izakhiwo eziyinkimbinkimbi.Izici zayo zamakhemikhali eziyingqayizivele kanye nokusebenza kabusha kuyenza ibe ithuluzi elibalulekile ekuthuthukisweni kwamabhizinisi amasha amakhemikhali.Osokhemikhali bangasebenzisa (3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one ukwethula amaqembu athile asebenzayo noma ukudala imolekyuli ethile. ama-scaffolds okufunda imisebenzi yebhayoloji yezinhlanganisela noma ukuthuthukisa imithi emisha.Ukwengeza, le nhlanganisela ingathola izinhlelo zokusebenza emkhakheni wesayensi yezinto ezibonakalayo.Ukuba khona kwayo njengeqembu elisebenzayo ku-molecule kungadlulisela izici ezithile ezifiselekayo ezintweni.Isibonelo, ingase ithuthukise ukuncibilika kuzinyibilikisi ezithile noma ithuthukise izici zokwenza ifilimu, iyenze ibe usizo ekubambisaneni noma ezintweni ezinamathelayo.(3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy) -6-(( i-triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one iyinhlanganisela ekhetheke kakhulu enokusetshenziswa okuhlukahlukene emikhakheni eyahlukene yesayensi nezimboni.Amandla ayo okusebenza njengeqembu elivikelayo futhi asebenze njengesakhiwo sokwakhiwa kwamakhemikhali okwenziwa, kanye nokusetshenziswa kwawo okungenzeka kusayensi yezinto ezibonakalayo, kuyenza ibe yingxenye ebalulekile ekuthuthukisweni kwama-molecule amasha nezinto zokwakha.Kodwa-ke, ukusetshenziswa kwayo okunembayo kanye nokusetshenziswa kungahluka, kuye ngezidingo ezithile nezinjongo zephrojekthi ethile yesayensi noma yezimboni.