Imikhiqizo

(3S) -3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran inhlanganisela yamakhemikhali okuyingxenye yesigaba sokuphuma kokuphuma kwe-tetrahydrofuran.Ivame ukusetshenziswa emkhakheni wocwaningo lwezemithi kanye nentuthuko ngenxa yezindawo zayo zokwelapha ezingaba khona.Enye yezicelo ezibalulekile zale nhlanganisela itholakala ekhonweni layo lokusebenzisana nama-receptors e-biological ahlukahlukene, ama-enzyme, noma amaprotheni emzimbeni womuntu.Lokhu kusebenzisana kungaholela ekuguqulweni kwezindlela ezithile ze-biochemical, okungenzeka kube nemiphumela yokwelapha.Abacwaningi bavame ukuhlola indima yenkomponi njengomuntu ongase abe umuthi wezifo ezihlukahlukene.Izici zesakhiwo senhlanganisela, okuhlanganisa ukuba khona kweringi ye-tetrahydrofuran kanye neqembu le-phenyl elithathelwe indawo, zifaka isandla ekwakhekeni kwayo kwemithi eyingqayizivele.Iqembu le-phenyl lihlinzeka ngokusebenzisana kwe-hydrophobic, okungase kuthinte ukunyibilika kwenhlanganisela kanye nokubopha okuhambisanayo ukuze kuqondiswe amaprotheni.Ukwengeza, ukuba khona kwama-athomu e-bromine ne-chlorine eringini ye-phenyl kwengeza ukuguquguquka ekusebenzeni kabusha kwamakhemikhali enhlanganisela, okungase kuvumele ukusebenzisana okuqondile nama-athomu ebhayoloji ahlosiwe.Ukuhlangana okubophezelayo nokukhetha kwe-(3S) -3-[4-[(5) -Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran kuma-receptors athile noma ama-enzyme anquma ukusetshenziswa kwayo kokwelapha okungaba khona.Ngenxa yalokho, abacwaningi baphenya ngemiphumela yayo ezintweni ezihlosiwe zamangqamuzana, njengama-receptors ahilelekile ekuvuvukeni, umdlavuza, noma ukuphazamiseka kwesistimu yezinzwa emaphakathi.Ocwaningweni lwangaphambi komtholampilo, abacwaningi bangase bahlole amandla, ukusebenza kahle, nokuphepha kwenhlanganisela.Ukuhlolwa okuhlukene kwebhayoloji namamodeli ezilwane angasetshenziswa ukuze kunqunywe indlela yokusebenza kwayo, ukumuncwa, ukusatshalaliswa, i-metabolism, kanye nokuphuma kwayo.Le datha ibalulekile ekuhloleni i-pharmacokinetics yenhlanganisela kanye nokuqonda ukuthi isebenzisana kanjani nomzimba womuntu. Nokho, kubalulekile ukuqaphela ukuthi (3S) -3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran isesigabeni socwaningo, futhi izinhlelo zayo zokwelapha ezingase zibe khona zisazohlolwa ngokugcwele.Ucwaningo olunzulu, okuhlanganisa nokuhlolwa kwemitholampilo kubantu, kungadingeka ukuze kunqunywe ukuphepha nokusebenza kwayo ngaphambi kokuba kucatshangelwe ukusetshenziswa kokwelapha.Ekuphetheni, (3S) -3-[4-[(5-Bromo-2-chlorophenyl)]methyl ]phenoxy]tetrahydrofuran okwamanje iyaphenywa ngezinhlelo zayo zokwelapha ezingaba khona emkhakheni wocwaningo lwezemithi.Isakhiwo salo samakhemikhali esiyingqayizivele sinomthelela ekusebenzisaneni okungase kube khona nezinhloso ezithile zebhayoloji, okuvula amathuba okuthuthukiswa kwama-ejenti anoveli okwelapha.Kodwa-ke, ucwaningo olwengeziwe nokuhlola kuyadingeka ukuze kutholwe amandla ayo eqiniso njengenhlanganisela yokwelapha.