Amagundane anikezwe umthamo owodwa wesitshalo semvelaphi ye-phenolic antioxidant Quercetin (QC) mahhala, i-liposome encapsulated kanye ne-galactosylated liposome ehlanganisiwe amafomu 2 h ngaphambi komthamo we-hepatotoxic we-carbontetrachloride (CCl4, 40% v / v emafutheni omnqumo, 1 ml / kg b .wt).Phakathi kwalezo zinhlobo ezintathu ezihlukene ze-QC ezihloliwe, i-galactosylated liposomal QC kuphela enikeze ukuvikeleka okubalulekile ekulimaleni kwe-CCl4 kwe-hepatic oxidative.Ngemuva kwehora le-24 lomjovo (SC) amaseli we-hepatic wamagundane atholakale esengozini yokulimala kwe-oxidative eyenziwe yi-CCl4 futhi iqashwe inani elikhulayo le-conjugated diene ku-membrane ye-hepatic.Ukwanda okuphindwe kabili kwe-conjugated diene ngokungeniswa kwe-CCl4 kwehliswe kwafika ezingeni elivamile ngokwelashwa kwangaphambili kwe-galactosylated liposomal QC.I-Carbontetrachloride idale ukulimala kwe-membrane kumaseli e-hepatic futhi yahlulelwa ukuhlolwa kwe-hepathological serum yegazi kanye nezicubu zesibindi.Ukulimala kwe-membrane ngokungeniswa kwe-CCl4 kwabuye kwahlaziywa ngezinga elinciphile le-enzyme ye-plasma (PM) eboshwe i-Na+/K+ ATPase futhi yandiswa kuphela ukwelashwa kwangaphambili kwe-galactosylated liposomal QC.I-Carbontetrachloride yenza ukwehla okukhulu kokubili kumazinga e-antioxidant e-enzymatic kanye ne-molecular endogenous kumaseli we-hepatic.Ukucindezeleka ohlelweni lwe-antioxidant kumaseli we-hepatic kwavinjelwa ngokuphelele umthamo owodwa we-galactosylated lipsosomal QC ngaphambi kokwelashwa kwe-CCl4.Ukutholwa kwesibindi kwe-QC kulinganiselwa ngemuva kwehora le-2 lomjovo we-flavonoid (8.9 micromol/kg isisindo somzimba) (amafomu amahhala noma e-liposomal) kanti i-85% ye-QC ejovwe itholakale esibindi uma kwenzeka i-galactosylated liposomal QC.Nakuba u-25% kuphela womthamo ojovwe utholwe esibindini lapho kujovwa inani elifanayo le-QC yamahhala.I-Carbontetrachloride nayo yenze ushintsho kulwelwesi lwe-fluidity futhi yahlolwa ngokuncipha kwe-membrane micro-viscosity.Ukwelashwa kwangaphambili kwe-QC kwamahhala kubangele ukuthi akukho ukuvikeleka ekukhuphukeni okubangelwa i-CCl4 ku-hepatic membrane fluidity, kanti i-galactosylated liposomal QC yenza isivikelo esibalulekile ekwandeni.Imiphumela yalolu cwaningo yembule ukuthi i-QC ku-galactosylated liposome ingenza isivikelo esibalulekile ekulimaleni kwe-hepatocellular CCl4.
