Imikhiqizo

I-4-Chlorophenylboronic acid iyinhlanganisela yemvelo ethola ukusetshenziswa okubanzi emikhakheni eyahlukene, okuhlanganisa ukwakheka kwemvelo, ikhemikhali yezokwelapha, kanye nesayensi yezinto ezibonakalayo.Iqukethe indandatho ye-phenyl efakwe esikhundleni seqembu le-chloro (-Cl) kanye neqembu le-boronic acid (-B(OH)2).Okunye ukusetshenziswa okuyinhloko kwe-4-Chlorophenylboronic acid indima yayo njenge-reagent ebalulekile ku-palladium-catalyzed. ukusabela okuhlanganayo, okufana nokusabela kwe-Suzuki-Miyaura ne-Heck.Lokhu kusabela kuhilela ukwakheka kwebhondi ye-carbon-carbon, lapho i-4-Chlorophenylboronic acid isebenza njengomthombo we-boron ongahlanganisa ama-electrophile ahlukahlukene ephilayo, njenge-aryl noma i-vinyl halides.Lokhu kuvumela ukuhlanganiswa kwenhlanganisela yezinto eziphilayo ezihlukahlukene, okuhlanganisa imithi, amakhemikhali e-agrochemicals, nezinto zokwakha.Ukwengeza, i-4-Chlorophenylboronic acid ingabuye ishintshwe amakhemikhali ukuze kwethule amaqembu asebenzayo engeziwe.Isibonelo, ingabhekana nokusabela kwe-amination ukuze yakhe i-4-chloro-phenylboronates, engaba usizo oluphakathi ekuhlanganiseni kwezinhlanganisela ezihlukahlukene eziqukethe i-nitrogen.Lokhu kuhlukahluka kweqembu elisebenzayo kuthuthukisa ukusetshenziswa kokwenziwa kwe-4-Chlorophenylboronic acid, okuvumela ukudalwa kwama-molecule ayinkimbinkimbi anezakhiwo ezihambisanayo.Okunye ukusetshenziswa okubalulekile kwe-4-Chlorophenylboronic acid ilele kumakhemikhali okwelapha.Ibonise isithembiso njenge-pharmacophore noma ibhulokhi yokwakha yokuthuthukisa ama-bioactive compounds.Ngenxa ye-boronate moiety, i-4-Chlorophenylboronic acid ingakha izibopho ezihlehliswayo ezihlangene nama-molecule aqukethe i-diol, njengama-carbohydrate nama-nucleotide.Lokhu kusebenzisana kuye kwasetshenziselwa ukuklama ama-enzyme inhibitors, ama-receptor ligand, namanye ama-ejenti emithi.Isibonelo, i-boronic acid-based proteasome inhibitors yenzelwe ukwelapha i-myeloma eminingi.Emkhakheni wesayensi yezinto zokwakha, i-4-Chlorophenylboronic acid ithole ukusetshenziswa ekuguqulweni kwezindawo noma ukuhlanganiswa kwezinto ezisebenzayo.Ngokusebenzisa iqembu le-boronic acid, lingakha ama-complexes aqinile ahlehliswayo ngama-polyols noma ama-compound ane-hydroxyl.Lesi sakhiwo singasetshenziselwa ukusebenza kahle kwendawo, njengokwakhiwa kwezingubo ezisabelayo ezishukumisayo noma ukulungiswa kwezinzwa zokuthola ama-carbohydrates noma ezinye izihlaziyi.Kafushane, i-4-Chlorophenylboronic acid iyinhlanganisela eguquguqukayo enezinhlelo zokusebenza ezihlukahlukene ku-organic synthesis, i-chemistry yezokwelapha. , kanye nesayensi yezinto.Ukusebenza kabusha kwayo ekwakhekeni kwebhondi ye-carbon-carbon, amandla okwethulwa kweqembu elisebenzayo, kanye nekhono lokwakha amabhondi e-covalent ahlehliswayo kuyenza ibe ithuluzi elibalulekile labacwaningi emikhakheni eyahlukene yesayensi.