I-5-Iodo-2'-deoxycytidine CAS:54-42-2 98-102% I-crystalline powder emhlophe
| Inombolo Yekhathalogi | XD90562 |
| Igama Lomkhiqizo | 5-Iodo-2'-deoxycytidine |
| I-CAS | 54-42-2 |
| I-Molecular Formula | I-C9H11IN2O5 |
| Isisindo samangqamuzana | 354.10 |
| Imininingwane Yesitoreji | 2 kuya ku-8 °C |
| Ikhodi Yentela Evumelanisiwe | 29349990 |
Ukucaciswa Komkhiqizo
| Ukubukeka | I-crystalline powder emhlophe |
| Isivivinyo | 99% |
| Ukuzungezisa okuqondile | +25 ukuze +30 |
| Izinsimbi ezinzima | <0.001% |
| Ukulahlekelwa Ekumisweni | <1.0% |
| Izinsalela ekushiseni | <0.3% |
Isakhiwo se-3D esibikezelwayo se-DNA enemicu ekabili siyenza ifaneleke njengesifanekiso sedizayini eya phansi phezulu yezindawo ezisebenzayo ezisuselwa ku-nucleic acid.Lapha sihlola ukusetshenziswa kwe-14mer DNA duplex njengesikafula sokuma okunembayo nokubikezelwa kokusebenza kwe-catalytic.Njengoba kunikezwe ukubamba iqhaza okukhona yonke indawo kweqembu le-imidazole elisekelwe ku-histidine ekuqashelweni kwamaprotheni kanye nezenzakalo ze-catalysis, ama-duplexes aguquliwe afana ne-histidine aphenywa.Ukusebenzisa i-histamine ku-C5 yesisekelo se-thymine nge-amide bond, kuvumela ukuma okuguquguqukayo komsebenzi we-imidazole emgodini omkhulu.Ukusebenzisana phakathi kwe-imidazole ne-duplex kanye nomthelela wayo ku-imidazolium pKaH kuphenywa ngokubeka i-thymine eyodwa eguquliwe ezindaweni ezine ezihlukene phakathi nendawo ye-14mer double helix.Kusetshenziswa i-NMR kanye nokuguquguquka kwamangqamuzana okungavinjelwe, i-motif yesakhiwo ehilela ukwakheka kwebhondi ye-hydrogen phakathi kwe-imidazole ne-Hoogste ohlangothini lwezisekelo ze-guanine zamapheya esisekelo se-GC amabili angomakhelwane ayasungulwa.I-motif inomthelela ekuzinziseni ngokumelene nokuncibilika okushisayo kwe-6 ° C futhi ibalulekile ekulungiseni i-pKaH yeqembu le-imidazolium.Izici ezijwayelekile, izimfuneko kanye nohlamvu olujwayelekile lwe-motif entsha elawula i-pKaH kuyachazwa.
