Imikhiqizo

I-5,6-Dihydro-3-(4-morpholinyl) -1-[4-(2-oxo-1-piperidinyl)phenyl]-2(1H)-pyridinone, eyaziwa nangokuthi i-DMPHP, iyinhlanganisela ye-heterocyclic enezinhlelo zokusebenza ezihlukahlukene. kukhemikhali yezokwelapha kanye nokutholakala kwezidakamizwa.Nansi incazelo yokusetshenziswa kwayo ngamagama angaba ngu-300. I-DMPHP yaziwa ngamandla ayo njengesivimbeli esinamandla nesikhethayo sama-enzyme athile nama-receptors emzimbeni womuntu.Enye yezinhlelo zayo eziyinhloko isendaweni ye-kinase inhibition.Ama-Kinase ama-enzyme adlala indima ebalulekile ezindleleni zokubonisa amaseli futhi avame ukuthinteka ezifweni ezihlukahlukene, kuhlanganise nomdlavuza.I-DMPHP itholwe ukuthi ivimbela ngokukhetha ama-kinase athile, ngaleyo ndlela iphazamise ama-cascade amasignali aphikisayo afaka isandla ekuqhubekeleni phambili kwesifo.Lokhu kwenza kube yikhandidethi elithembisayo lokuthuthukiswa kwemithi yokwelapha ehlosiwe yezifo eziningi, kuhlanganise nomdlavuza, ukuvuvukala, nokuphazamiseka kwezinzwa.Ngaphezu kwalokho, i-DMPHP ibonise amandla endaweni yomsebenzi wokulwa nokuvuvukala kanye ne-immunomodulatory.Ukuvuvukala kuwukusabela okungokwemvelo komzimba ekuthelelekeni noma ekulimaleni kodwa kungaba okungapheli futhi kubangele izifo ezihlukahlukene.I-DMPHP ibonise ikhono lokuvimbela izindlela ezithile ezikhuthaza ukuvuvukala, ukunciphisa ukukhiqizwa kwabalamuli abavuvukalayo.Lesi sakhiwo sikwenza ithuluzi elibalulekile ekwakhiweni kwemithi elwa nokuvuvukala, esiza ekwelapheni izimo ezifana nesifo samathambo, isifo samathumbu esivuvukalayo, kanye nesifuba somoya.I-DMPHP iphinde yaphenywa ngamandla ayo njenge-analgesic noma i-ejenti edambisa izinhlungu. .Ubuhlungu obungapheli buyinkinga yezempilo ebalulekile, futhi izinketho zamanje zokwelapha ngokuvamile zinemikhawulo noma imiphumela emibi engadingeki.I-DMPHP ibonise imiphumela ye-analgesic ezifundweni zangaphambi komtholampilo, iphakamisa amandla ayo njengenoveli yokwelapha yokulawula ubuhlungu.Ngokuhlela ama-receptors athile kanye nama-neurotransmitters ahilelekile ekuzweleni ubuhlungu, i-DMPHP ingase inikeze enye indlela yokulawula ubuhlungu okungenzeka ibe nemiphumela engemihle embalwa.Ukwengeza, i-DMPHP ibonise isithembiso emkhakheni wezinkinga zesistimu yezinzwa ezimaphakathi (CNS).Izimo zemizwa njengesifo i-Alzheimer kanye nesifo sikaParkinson zibandakanya izindlela eziyinkimbinkimbi kanye nokungasebenzi kahle kwama-receptors nama-enzyme ahlukahlukene ebuchosheni.I-DMPHP iye yafundelwa amandla ayo njenge-ejenti yokuvikela izinzwa kanye nekhono layo lokuthuthukisa ukusebenza kwengqondo.Ngokukhomba ama-receptors athile kanye nezindlela ezihilelekile ekuphazamisekeni kwe-neurodeergenerative, i-DMPHP inesithembiso njengokungenelela kokwelapha kulezi zimo eziyinselele. I-1-piperidinyl)phenyl]-2(1H) -pyridinone (DMPHP) iyinhlanganisela eguquguqukayo enezinhlelo zokusebenza ezingase zibe khona ekuvimbeleni i-kinase, umsebenzi wokulwa nokuvuvukala, i-analgesia, ne-neuroprotection.Amandla ayo okushintsha ngokukhetha ama-enzyme athile nama-receptors abandakanyeka ezindleleni zezifo ayenza ibe ikhandidethi elikhangayo lokutholwa kwezidakamizwa nokungenelela kokwelapha.Ucwaningo olwengeziwe nokuthuthukiswa kungase kuveze ukusetshenziswa okwengeziwe futhi kuthuthukise izakhiwo zayo ukuze kube nezinkomba ezithile.