Imikhiqizo

I-Acetoxy Empagliflozin, eyaziwa nangokuthi i-empagliflozin acetate, iwuhlobo olushintshiwe lomuthi we-antidiabetic empagliflozin.I-Empagliflozin ingeyesigaba sezidakamizwa ezaziwa ngokuthi i-sodium-glucose co-transporter 2 (SGLT2) inhibitors, esetshenziselwa ngokuyinhloko ukuphatha uhlobo 2 lwesifo sikashukela. I-Empagliflozin isebenza ngokuvimbela i-SGLT2, iphrotheni enesibopho sokumunca kabusha ushukela ezinso.Ngokuvimbela le phrotheni, i-empagliflozin ithuthukisa ukuphuma kwe-glucose ngomchamo, okuholela ekwehleni kwezinga likashukela egazini kubantu abanesifo sikashukela.I-Acetoxy Empagliflozin iphuma ku-empagliflozin eshintshwe ngokufakwa kweqembu le-acetoxy.Lokhu kuguqulwa kuhloswe ukuthuthukisa ukuzinza nokuba khona kwe-bioavailability yomuthi, okungase kuholele emiphumeleni yokwelapha ethuthukisiwe. Ukusetshenziswa okuyinhloko kwe-Acetoxy Empagliflozin kusalokhu kugxile ekulawulweni kohlobo 2 lwesifo sikashukela.Uma ithathwa ngomlomo, yenza ngokunciphisa ukumuncwa kabusha kwe-glucose ye-renal, okuholela ekwandeni kokuphuma kwe-glucose yomchamo.Le nqubo isiza ukwehlisa amazinga kashukela egazini futhi ithuthukise ukulawulwa kwe-glycemic ezigulini ezinesifo sikashukela sohlobo 2. Ngaphezu kwemiphumela yayo yokwehlisa ushukela, ama-SGLT2 inhibitors afana ne-Acetoxy Empagliflozin aboniswe ukuthi anezinzuzo zesibili.Lokhu kufaka phakathi ukuthuthukiswa okungenzeka emiphumeleni yenhliziyo, njengokunciphisa ingozi yokufa kwenhliziyo, ukuhluleka kwenhliziyo, kanye nesifo sohlangothi.Kungase futhi kuholele ekuncipheni kwesisindo somzimba, ekwehliseni izinga lomfutho wegazi, nokunciphisa isidingo se-insulini noma eminye imishanguzo ye-antidiabetic.Kubalulekile ukuqaphela ukuthi i-Acetoxy Empagliflozin, njengamanye ama-SGLT2 inhibitors, ayinconyelwe kubantu abanesifo sikashukela sohlobo loku-1 noma labo abanesifo sikashukela. i-ketoacidosis.Ngokuvamile kunqunywa kanye nokuguqulwa kwendlela yokuphila, okuhlanganisa ukudla nokuzivocavoca, ukuze kulawuleke isifo sikashukela. Njenganoma yimuphi umuthi, i-Acetoxy Empagliflozin ingase ibe nemiphumela engemihle engaba khona, okuhlanganisa izifo zomzila womchamo, izifo ze-mycotic (yeast), ukwanda kokuchama, isiyezi, kanye ne-hypoglycemia. .Kubalulekile ukuthi abantu abaphuza lo muthi baqaphe ngokucophelela amazinga kashukela egazini futhi babike noma yimiphi imiphumela emibi kubahlinzeki babo bezempilo.Isebenza njenge-SGLT2 inhibitor, esiza ukwehlisa amazinga kashukela egazini ezigulini ezinesifo sikashukela sohlobo 2 ngokwandisa ukuphuma kweglucose kumchamo.Ingase futhi inikeze izinzuzo ezengeziwe, njengezinzuzo ezingaba khona zenhliziyo nemithambo yegazi kanye nesisindo.Kodwa-ke, njenganoma yimuphi umuthi, kubalulekile ukulandela isiqondiso sochwepheshe bezempilo futhi uqaphe ngokucophelela noma yimiphi imiphumela emibi engaba khona.