Imikhiqizo

Ijeli ye-Chitosan-dextran isetshenziswe njenge-ejenti ye-antihemostatic kanye ne-anti-adhesive agent ngemva kokuhlinzwa kwe-endoscopic sinus.Ngenxa yokuthi i-Staphylococcus aureus biofilms iye yathinteka ku-rhinosinusitis engapheli, lolu cwaningo luhlose ukuqhubeka nokuphenya (i) ukulwa nokuvuvukala, (ii) ukuvimbela i-biofilm yebhaktheriya, (iii) imiphumela evimbela ukukhula, kanye (iv) nezindawo zokupholisa amanxeba ze-chitosan kanye. I-chitosan-dextran gel.I-Fibroblasts yahlukaniswa nezicubu zekhala lomuntu futhi yasetshenziselwa ukunquma imiphumela ye-chitosan ne-chitosan-dextran gel (i) ekwandeni kwamaseli, (ii) ukuphulukiswa kwesilonda, (iii) ukuvuvukala emasikweni e-fibroblast inselele ngama-superantigens S. .aureus enterotoxin B (SEB) kanye ne-toxic shock syndrome toxin (TSST), kanye (iv) ku-S. aureus biofilms.I-Chitosan ibisebenza kahle kakhulu ekwehliseni isisho se-IL-8 ngemva kwenselele ye-TSST ne-SEB.I-Chitosan iphinde yasebenza kahle ekwehliseni ukubonakaliswa kwe-IL-8 kwe-fibroblasts engaphonswanga inselele ekhombisa imiphumela yayo yokulwa nokuvuvukala kuma-fibroblasts esimweni esidaliwe.Ijeli ye-Chitosan-dextran ibonise izakhiwo eziqinile ze-antibiofilm ku-50% (v/v) ukugxila ku-vitro.I-Dextran, ngokwayo, ibonise izakhiwo ze-antibiofilm ekugxilweni kwe-1.25% (w / v).I-Chitosan, ngokwayo, inciphise ukwanda kwe-fibroblasts kuya ku-82% yokulawula ukwanda kanye nejeli ye-chitosan-dextran yehlisa ukusabalala kwe-fibroblasts kuya ku-0.04% yokwanda kokulawula.Ngokuphathelene nokulawulwa okungekho zokwelapha, ijeli ye-chitosan-dextran yabambezeleka kakhulu izinga lokuphulukiswa kwesilonda emahoreni okuqala angu-48 okuhlolwa. isikhathi.I-Chitosan yehlise amazinga e-IL-8, ikhombisa izakhiwo zayo zokulwa nokuvuvukala.Ijeli ye-Chitosan-dextran kanye nokwelashwa kwe-dextran kubonise izakhiwo ze-antibiofilm kumodeli yethu.