Imikhiqizo

I-Benzyl N-({hexahydro-1H-pyrrolizin-7a-yl}methyl)carbamate hydrochloride iyinhlanganisela yamakhemikhali engase isetshenziswe emkhakheni wezokwelapha kanye nocwaningo lwezemithi.Iqukethe iqembu le-benzyl elixhunywe ekusebenzeni kwe-carbamate, yona exhunywe ku-hexahydro-1H-pyrrolizin-7a-ylmethyl moiety.Ukwengezwa kwe-hydrochloride ku-compound kubonisa ukuba khona kwe-ion ye-chloride, ethuthukisa ukuncibilika kwayo emanzini.Le nhlanganisela ingase ibe nokusetshenziswa okuningana ngenxa yezici zayo zesakhiwo.I-Carbamates, ngokuvamile, iyaziwa ngokubonisa imisebenzi yebhayoloji eyahlukene, okuhlanganisa i-anticonvulsant, i-anticancer, kanye nezakhiwo ze-antihypertensive.Ukuba khona kweqembu le-benzyl ku-benzyl N-({hexahydro-1H-pyrrolizin-7a-yl}methyl)carbamate hydrochloride kunganikeza i-lipophilicity ethuthukisiwe, okuyivumela ukuthi yeqe kalula ulwelwesi lwamaselula.Lokhu kungaba yinzuzo ekulethweni kwezidakamizwa kanye nokwenza ngcono i-bioavailability.I-Hexahydro-1H-pyrrolizin-7a-ylmethyl moiety, eyaziwa nangokuthi i-piperidinyl moiety, ivame ukutholakala kuma-bioactive compounds.Ama-Piperidine aziwa ngendima yawo njengama-enzyme inhibitors, ama-neurotransmitter modulators, nama-anti-inflammatory agents.Ukufakwa kwalesi siqephu esakhiweni kungase kuthuthukise umsebenzi walo webhayoloji namandla okwelapha.Naphezu kokuntuleka kolwazi oluthile mayelana nokuhlola noma ukusetshenziswa komtholampilo kwenhlanganisela, izicelo ezingase zibe khona zingacatshangwa ngokusekelwe ezintweni ezaziwayo zamaqembu akhona.I-Benzyl N-({hexahydro-1H-pyrrolizin-7a-yl}methyl)carbamate hydrochloride ingase ihlolwe njengekhandidethi lesidakamizwa esingaba khona ezimweni ezifana nesifo sokuwa, umdlavuza, umfutho wegazi ophezulu, noma ukuphazamiseka kwemizwa.Ingase futhi isetshenziswe njengesakhiwo sokwakha noma esimaphakathi ekuhlanganiseni ezinye izinhlanganisela ze-bioactive. Kubalulekile ukuqaphela ukuthi ngaphambi kwanoma yisiphi isicelo esingokoqobo noma uphenyo olwengeziwe, ucwaningo olunzulu nokuhlola okuhlanganisa izifundo ze-toxicological, ukuthuthukiswa kwamakhemikhali emithi, nokuhlola okuphambene nalokho okuhlosiwe. kufanele kwenziwe.Lokhu kuzosiza ekunqumeni ukuphepha, ukusebenza kahle, kanye nendlela eqondile yokusebenza kwe-benzyl N-({hexahydro-1H-pyrrolizin-7a-yl}methyl)carbamate hydrochloride, ekugcineni kuholele ekusetshenzisweni kwayo okungaba khona emkhakheni wezokwelapha.