Imikhiqizo

I-metabolite yebhaktheriya yamathumbu ye-ginseng protopanaxadiol saponin, 20-O-(β-D-glucopyranosyl) -20(S)-protopanaxadiol (inhlanganisela K), kubikwe ukuthi yenza i-apoptosis kumaseli omdlavuza ahlukahlukene.Kodwa-ke, izindlela eziqondile ezidalwe i-compound K kumaseli we-hepatocellular carcinoma (HCC) yabantu ahlala engacacile.Ukuze sihlole izindlela ezingenzeka ze-apoptotic, siphenye umphumela we-anticancer we-compound K ku-MHCC97-H.Ukuhlolwa kwe-MTT kubonise ukuthi i-compound K ivimbele ukwanda kwamaseli e-MHCC97-H anobuthi obuphansi kakhulu kumaseli avamile we-hepatoma.Ukuqhubeka komjikelezo weseli nokungcoliswa kwamaseli kubonise ukwanda kwengxenye ye-apoptotic sub-G1.Ukwelashwa kwe-MHCC97-H nge-compound K kuphinde kwabangela ukuncishiswa kwamandla olwelwesi lwe-mitochondrial (Δψm) nokulimala kwe-DNA.Ucwaningo olwengeziwe lubonise ukuthi i-compound K ilawula isilinganiso se-Fas, i-FasL, i-Bax/Bcl-2 kanye ne-pro-caspase-9 yehliselwa phansi, i-pro-caspase-3 ngendlela encike kumthamo, futhi yavimbela i-Akt phosphorylation.Le miphumela iphakamisa ukuthi i-compound K ivimbela kakhulu ukwanda kwamaseli futhi ibangele i-apoptosis kumaseli e-MHCC97-H ngokusebenzisa izindlela ezincike ku-Fas- kanye ne-mitochondria-mediated caspase kumaseli e-HCC yomuntu.