I-Acriflavine, i-neutral Cas: 8048-52-0 Iwolintshi ukuya kokubomvu kuya kumpushana obomvu-nsundu
| Inombolo Yekhathalogi | XD90521 |
| Igama Lomkhiqizo | I-Acriflavine, ingathathi hlangothi |
| I-CAS | 8048-52-0 |
| I-Molecular Formula | I-C14H14ClN3 |
| Isisindo samangqamuzana | 259.73 |
| Imininingwane Yesitoreji | I-ambient |
| Ikhodi Yentela Evumelanisiwe | 38249993 |
Ukucaciswa Komkhiqizo
| Ukubukeka | Okuwolintshi kuya kokubomvu kuya kokubomvu kuya kwempushana ensundu |
| Isivivinyo | 99% |
| AS | 10ppm ubuningi |
| Ukulahlekelwa Ekumisweni | 8% ubuningi |
| Amanzi angancibiliki | 0.5% ubuningi |
| Umlotha one-sulfate | 3.5% ubuningi |
| Ukuhlolwa kokuqukethwe kwe-chlorine komile @ 105 Deg C amahora ama-2 | 13.3 - 15.8% |
Imithi eminingi elwa nomdlavuza iyehluleka ukuqeda izimila, okuholela ekwakhekeni kokungazweli emishanguzweni nokuphindelela kwezifo.Ukusayinda i-Hedgehog kudlala indima ebalulekile ngesikhathi sokukhula kombungu, kodwa futhi kubandakanyeka ekuthuthukisweni komdlavuza, ukuqhubeka, kanye ne-metastasis.I-Hedgehog receptor Patched (Ptc) iwufuzo oluqondiswe ku-Hedgehog oluvezwa ngokweqile kumaseli amaningi omdlavuza.Lapha, sibonisa ukuxhumana phakathi kwe-Ptc nokumelana nokwelashwa ngamakhemikhali, futhi sinikeza ukuqonda okusha ngomsebenzi we-Ptc.I-Ptc isuswa kulwelwesi lwe-plasma lapho isebenzisana ne-ligand Hedgehog, noma lapho ukwelashwa kwamaseli nge-Hedgehog esayina i-antagonist cyclopamine.Kuzo zombili izimo, ngemuva kokufakwa kwamangqamuzana ane-doxorubicin, i-chemotherapeutic agent esetshenziselwa ukwelapha umdlavuza ovela kaningi, sabona ukuvinjelwa kokuphuma kwe-doxorubicin kuma-fibroblasts aphendula i-Hedgehog, kanye nokwanda kokuqoqwa kwe-doxorubicin kumdlavuza ohlukene. imigqa yeseli eyaziwa ukuthi iveza amazinga e-aber rant wezingxenye zokusayina ze-Hedgehog.Sisebenzisa i-heterologous expression system, sibonise ngokuqinile ukuthi ukuvezwa kwe-Ptc yomuntu kunikeza ukumelana nokuvimbela ukukhula ngezidakamizwa ezimbalwa okuvela kuzo ama-chemotherapeutic agents afana ne-doxorubicin, methotrexate, temozolomide, ne-5-fluorouracil.Ukumelana ne-doxorubicin okuhlotshaniswa nomsebenzi we-Ptc, njengoba kuboniswa kusetshenziswa ukuguqulwa kweziguli ze-Gorlin's syndrome lapho kulahleka umphumela we-Ptc-mediated ekuboniseni i-Hedgehog.Imiphumela yethu ibonisa ukuthi i-Ptc ibandakanyeka emfucumfucwini nasekumelaneni nezidakamizwa eziningi, futhi iphakamisa ukuthi i-Ptc inegalelo ekwelapheni ngamakhemikhali amangqamuzana omdlavuza.
