I-Fluorescein CAS:2321-07-5 I-Orange i-crystalline powder ebomvu
| Inombolo Yekhathalogi | XD90459 |
| Igama Lomkhiqizo | I-Fluorescein |
| I-CAS | 2321-07-5 |
| I-Molecular Formula | I-C20H12O5 |
| Isisindo samangqamuzana | 332.31 |
| Imininingwane Yesitoreji | I-ambient |
| Ikhodi Yentela Evumelanisiwe | 32129000 |
Ukucaciswa Komkhiqizo
| Ukubukeka | I-Orange/i-crystalline powder ebomvu |
| Isivivinyo | 99% |
| Ukulahlekelwa Ekumisweni | 1% ubuningi |
Iphrotheni ye-cerebral dopamine neurotrophic factor (CDNF) ikhonjiswe ukuthi ivikela indlela ye-nigrostriatal dopaminergic lapho inikezwa njengokungeniswa kwe-intrastriatal kumamodeli wamagundane namagundane esifo sika-Parkinson (PD).Kulolu cwaningo, sihlole umphumela we-neuroprotective we-CDNF olethwe nge-recombinant adeno-associated viral (AAV) serotype 2 vector kumodeli ye-rat 6-hydroxydopamine (6-OHDA) ye-PD.Amavekhtha e-AAV2 afaka ikhodi i-CDNF, i-glial cell-derived neurotrophic factor (GDNF), noma iphrotheni ye-fluorescent eluhlaza ajovwe ku-rat striatum.Ukuhlaziywa kwe-protein expression kubonise ukuthi i-AAV2 vector yethu ilethe ngempumelelo izakhi zofuzo ze-neurotrophic factor ebuchosheni futhi yanikeza ukubonakaliswa okuhlala isikhathi eside kwamaprotheni.Emasontweni amabili ngemuva komjovo we-vector ye-AAV2, i-6-OHDA yajovwa ku-rat striatum, okwenza ukonakala okuqhubekayo kohlelo lwe-nigrostriatal dopaminergic.Ukwelashwa nge-AAV2-CDNF kuphumele ekwehleni okuphawulekayo kokujikeleza kwe-ipsilateral okubangelwa i-amphetamine kuyilapho kunikeza ukuvikelwa okuncane kuphela kwamaseli e-tyrosine hydroxylase (TH) -immunoreactive ku-rat substantia nigra pars compacta kanye nemicu esebenzayo ye-TH ku-striatum.Imiphumela evela kulolu cwaningo inikeza ubufakazi obengeziwe bokuthi i-CDNF ingabhekwa njengokwelashwa okungenzeka kwesifo sikaParkinson.
