I-Citicoline sodium Cas:33818-15-4 CYTIDINE-5′-DIPHOSPHOCHOLINE
| Inombolo Yekhathalogi | XD90590 |
| Igama Lomkhiqizo | I-Citicoline sodium |
| I-CAS | 33818-15-4 |
| I-Molecular Formula | I-C14H25N4NaO11P2 |
| Isisindo samangqamuzana | 510.31 |
| Imininingwane Yesitoreji | -20°C |
| Ikhodi Yentela Evumelanisiwe | 29349990 |
Ukucaciswa Komkhiqizo
| Ukubukeka | Okuqinile Okumhlophe |
| Isivivinyo | 99% |
| Iphoyinti lokuncibilika | 250°C(dec.)(lit.) |
| Iphuzu elibilayo | °Cat760mmHg |
| I-PSA | 238.17000 |
| logP | -0.14090 |
| Ukuncibilika | I-H2O: 100mg/mL |
I-Citicoline (CDP-choline) ingumxhumanisi oyinhloko ku-biosynthesis ye-phosphatidylcholine, ingxenye ebalulekile ye-neural cell membrane.Iboniswe ukuthi ikhiqiza imiphumela enenzuzo kuzo zombili izinhlobo zezilwane kanye nokuhlolwa kwe-stroke okungewona okwase-US.Lolu cwaningo luhlanganisa okungahleliwe (imithamo emi-3 ye-citicoline ku-placebo engu-1), isilingo esilawulwa yimoto, esingaboni kabili ezikhungweni ezingama-21 zase-US.Ukwelashwa kwakuzoqalwa phakathi namahora angu-24 ngemva kokuqala kwe-stroke futhi kwaqhutshekwa ngomlomo amasonto angu-6.Ukuhlolwa kwemiphumela yokugcina bekusemavikini ayi-12.Iziguli ezingamakhulu amabili namashumi amahlanu nesishiyagalolunye zabhaliswa, cishe nezingama-65 eqenjini ngalinye kwamane.Isikhathi esimaphakathi kusukela ekushayweni kwesifo sohlangothi kuya ekwelapheni kwakungamahora angu-14.5, futhi kwakungekho umehluko omkhulu ezicini eziyisisekelo phakathi kwamaqembu amane ngaphandle kwesisindo sesiguli.Umehluko omkhulu phakathi kwamaqembu, okuvuna ukwelashwa kwe-citicoline, ubonwe ngokomphumela wokusebenza njengoba kukalwa i-Barthel Index kanye nesilinganiso se-Rankin, ukuhlolwa kwe-neurologic njengoba kukalwa isikali sohlangothi seNational Institutes of Health (NIH), kanye nomsebenzi wokuqonda njengoba kukalwa Ukuhlolwa Kwesimo Sengqondo Esincane.Lapho isisekelo se-NIH stroke scale sisetshenziswa njenge-covariate, kokubili iqembu le-citicoline le-500-mg kanye neqembu le-citicoline le-2,000-mg libe nokuthuthuka okuphawulekayo ngokwephesenti leziguli ezibe nomphumela omuhle ku-Barthel Index ezinsukwini ze-90.Azikho izehlakalo ezimbi kakhulu ezihlobene nezidakamizwa noma ukufa kulolu cwaningo.Lolu cwaningo luphakamisa ukuthi i-citicoline yomlomo ingasetshenziswa ngokuphepha ngemiphumela engemihle emincane ekwelapheni kwe-acute stroke.I-Citicoline ibonakala ithuthukisa umphumela wokusebenza futhi yehlise ukushoda kwe-neurologic nge-500 mg ye-citicoline ebonakala iyidosi efanelekile.
