I-Clozapine N-oxide CAS:34233-69-7
| Inombolo Yekhathalogi | XD90469 |
| Igama Lomkhiqizo | I-Clozapine N-oxide |
| I-CAS | 34233-69-7 |
| I-Molecular Formula | I-C18H19ClN4O |
| Isisindo samangqamuzana | 342.823 |
| Imininingwane Yesitoreji | 2 kuya ku-8 °C |
| Ikhodi Yentela Evumelanisiwe | 29335990 |
Ukucaciswa Komkhiqizo
| I-Melting Point | 190-248 °C |
| Ukubukeka | Impushana emhlophe |
| Isivivinyo | 99% |
Umthelela ongemuhle ubalulekile ekunikezeni ubungozi bokulutha kwe-opiate njengoba kuboniswa yi-comorbidity ephezulu yokuhlukunyezwa kwe-opiate nge-depressive disorder enkulu (MDD).Amamodeli wamagundane afaka i-amygdala prodynorphin (Pdyn) njengomlamuleli wokuthinta okungalungile;kodwa-ke, ubufakazi bokubandakanyeka kwe-PDYN ekuthinteni okungekuhle kwabantu kunqunyelwe.Lapha, sithole isisho esincishisiwe se-PDYN mRNA ku-postmortem human amygdala nucleus ye-periamygdaloid cortex (PAC) kubo bobabili abahlukumezi be-heroin nezihloko ze-MDD.Ngokufanayo nabantu, amagundane i-heroin ezilawulayo aye ehlise isisho se-Pdyn mRNA ku-PAC ngesikhathi esihlotshaniswa nesimo sokuthinteka esibi.Sisebenzisa ubuchwepheshe bokucabanga obusebenzayo be-in vivo i-DREAMM (imephu ye-metabolic esiza i-DREADD, lapho i-DREADD ikhombisa ama-designer receptors acushwe ngokukhethekile izidakamizwa eziklami), sithole ukuthi ukuvinjwa okukhethekile kwama-neurons aveza i-Pdyn ku-PAC yegundane kwandise umsebenzi we-metabolic ku-amygdala enwetshiwe, okuyinto iyingxenye ebalulekile yesistimu yokucindezeleka kwengqondo ye-extrahypothalamic.Ngokuhambisanayo, i-PAC-specific Pdyn inhibition yavusa izinguquko ezimbi ezihlobene nomthelela wokuphila nokuziphatha.Sekukonke, ucwaningo lwethu lokuhumusha lusekela indima esebenzayo ye-Pdyn ekhubazekile ku-PAC ekuhlukunyezweni kwe-opiate ngokwenza kusebenze ingcindezi kanye nomthelela ongemuhle we-neurocircuitry obandakanyeka ekubeni sengozini yokulutha.
