I-D-Glutamic acid CAS: 6893-26-1 99% Impuphu emhlophe
| Inombolo Yekhathalogi | XD90313 |
| Igama Lomkhiqizo | I-D-Glutamic acid |
| I-CAS | 6893-26-1 |
| I-Molecular Formula | I-C5H9NO4 |
| Isisindo samangqamuzana | 147.13 |
| Imininingwane Yesitoreji | I-ambient |
| Ikhodi Yentela Evumelanisiwe | 29224200 |
Ukucaciswa Komkhiqizo
| Ukubukeka | I-crystalline powder emhlophe |
| Isivivinyo | 99% |
| Ukuzungezisa okuqondile | -31 kuya ku-32.2 |
| Izinsimbi ezinzima | <10ppm |
| AS | <1ppm |
| pH | 3 - 3.5 |
| I-SO4 | <0.020% |
| Fe | <10ppm |
| Ukulahlekelwa Ekumisweni | <0.20% |
| Izinsalela ekushiseni | <0.10% |
| NH4 | <0.02% |
| Cl | <0.02% |
| Isimo Sesixazululo | >98% |
I-γ-Glutamyltranspeptidases (γ-GTs) ihlukanisa ibhondi ye-γ-glutamyl amide ye-glutathione futhi idlulisele iqembu elikhululiwe le-γ-glutamyl emanzini (hydrolysis) noma ama-amino acid owamukelayo (transpeptidation).Lawa ma-enzyme atholakala yonke indawo adlala indima ebalulekile ekwenziweni kwe-biosynthesis kanye nokuwohloka kwe-glutathione, nasekukhipheni ubuthi be-xenobiotic.Lapha sibika ukwakheka kwekristalu kwe-3Å kwe-Bacillus licheniformis γ-GT (BlGT) kanye nalokho okuyinkimbinkimbi yayo ene-l-Glu.Izakhiwo ze-X-ray ziqinisekisa ukuthi i-BlGT ingeyomndeni omkhulu we-N-terminal nucleophilic hydrolase futhi iveza ukuthi iphrotheni inendawo evulekile evulekayo efana naleyo ebikwe i-enzyme ye-homologous evela ku-Bacillus subtilis, kodwa ehlukile kulawo aqashelwa i-γ-GT yomuntu kanye. ama-γ-GT avela kwamanye ama-microorganisms.Idatha iphakamisa ukuthi ukuboshwa kwe-l-Glu kudala ukuhleleka kabusha komsila we-C weyunithi enkulu ye-BlGT futhi kuvumela ukukhonjwa kweqoqo lezinsalela ze-asidi okungenzeka zihileleke ekubonweni kwe-ion yensimbi.Indima yalezi zinsalela ekuzinzeni kokuvumelana kwe-BlGT iye yacutshungulwa ngokufaka uphawu lokucutshungulwa ngokuzenzakalela, umsebenzi we-enzymatic, amakhemikhali kanye nokushintshashintsha kwe-thermal kwezishintshayo ezine ze-Ala eyodwa.Imiphumela ibonisa ukuthi ukushintshwa kwe-Asp568 nge-Ala kuthinta kokubili ukucubungula ngokuzenzakalela kanye nokuzinza kwesakhiwo sephrotheni.
