I-L-Glutamic acid CAS:56-86-0 99% Impushana Emhlophe
| Inombolo Yekhathalogi | XD90312 |
| Igama Lomkhiqizo | I-D-Glutamic acid |
| I-CAS | 56-86-0 |
| I-Molecular Formula | I-C5H9NO4 |
| Isisindo samangqamuzana | 147.13 |
| Imininingwane Yesitoreji | I-ambient |
| Ikhodi Yentela Evumelanisiwe | 29224200 |
Ukucaciswa Komkhiqizo
| Ukubukeka | I-Crystal Emhlophe noma I-Crystalline Powder |
| Isivivinyo | 99% |
| Ukuzungezisa okuqondile | +31,5 ukuze +32.5° |
| pH | 3.0 kuye ku-3.5 |
| Ukulahlekelwa Ekumisweni | 0.2% ubuningi |
| Insimbi | 10 ppm ubuningi |
| I-AS2O3 | 1 ppm ubuningi |
| Insimbi enzima(Pb) | 10 ppm ubuningi |
| I-ammonium | 0.02% ubuningi |
| Amanye ama-amino acid | <0.4% |
| I-Chloride | 0.02% ubuningi. |
| Izinsalela ekushiseni (Sulfated) | 0.1% ubuningi |
| I-Sulfate (njenge-SO4) | 0.02% ubuningi |
I-EAAT2 glutamate transporter, yenza >90% we-hippocampal glutamate ethathayo.Nakuba i-EAAT2 ivezwa kakhulu kuma-astrocyte, ~10% wama-molecule e-EAAT2 atholakala kumatheminali e-axon.Ngaphandle kwezinga eliphansi lenkulumo ye-EAAT2 kumatheminali e-glutamatergic, lapho izingcezu ze-hippocampal zifakwe ngokugxiliswa okuphansi kwe-d-aspartate (i-EAAT2 substrate), amatheminali e-axon aqongelela i-d-aspartate ngokushesha njenge-astroglia.Lokhu kusho ukungafani okungachazwanga phakathi kokusatshalaliswa kwephrotheni ye-EAAT2 kanye nomsebenzi wezokuthutha owenziwe nge-EAAT2.Inkolelo-mbono eyodwa iwukuthi (1) ukushintshaniswa kwe-heteroexchange ye-substrate yangaphakathi ne-substrate yangaphandle kushesha kakhulu kunokuthatha inetha futhi (2) amatheminali athanda ukushintshaniswa kwe-heteroexchange ngenxa yamazinga aphezulu e-glutamate yangaphakathi.Kodwa-ke, okwamanje akwaziwa ukuthi i-heteroexchange nokuthatha kunezilinganiso ezifanayo noma ezihlukile.Ukuze sibhekane nale nkinga, sisebenzise isistimu ehlanganiswe kabusha ukuze siqhathanise izilinganiso ezihambisanayo zezinqubo ezimbili kumagundane namagundane.Ukuthathwa kwensalela kwaba nomuzwa wokuthi kunezinguquko kulwelwesi olunamandla futhi kwagqugquzelwa ama-anion angaphandle avunyelekayo ngokuvumelana nokuba khona kokuqhutshwa kwe-anion okungahlanganisiwe.Ngokusebenzisa lokhu kwakamuva, sibonisa futhi ukuthi izinga le-heteroexchange lincike emandleni olwelwesi.Ukwengeza, idatha yethu iphakamisa nokuba khona kokuvuza kwe-sodium ku-EAAT2.Ngokuhlanganisa okutholakele okusha kumodeli yethu yangaphambilini yokuthatha i-glutamate nge-EAAT2, sibikezela ukuthi ukuzwela kwe-voltage yokushintshana kubangelwe ukubophezela kwe-Na(+) yesithathu okuncike ku-voltage.Ngaphezu kwalokho, kokubili ukuhlola kwethu nokulingiswa kuphakamisa ukuthi amanani ahlobene okuthathwa kwensalela kanye ne-heteroexchange ayaqhathaniswa ku-EAAT2.
