I-D-Valine Cas: 640-68-6 C5H11NO2
| Inombolo Yekhathalogi | XD90291 |
| Igama Lomkhiqizo | D-Valine |
| I-CAS | 640-68-6 |
| I-Molecular Formula | I-C5H11NO2 |
| Isisindo samangqamuzana | 117.14634 |
| Imininingwane Yesitoreji | I-Temp yegumbi |
| Ikhodi Yentela Evumelanisiwe | 29224995 |
Ukucaciswa Komkhiqizo
| Isivivinyo | 99% |
| Ukubukeka | Impushana emhlophe |
| Ukuminyana | 1.2000 (isilinganiso) |
| Iphoyinti lokuncibilika | >295 °C (i-subl.) (ekhanyayo) |
| Iphuzu elibilayo | 213.6 °C ku-760 mmHg |
| Iphoyinti le-Flash | 83℃ |
| Inkomba ye-refractive | -27 ° (C=8, 6mol/L HCl) |
| Ukuncibilika | 56 g/L (20°C) |
| Ukuncibilika kwamanzi | 56 g/L (20 ºC) |
| I-PSA | 63.32000 |
| I-LogP | 0.75460 |
| Ukuzungezisa okuqondile | -27.5 º (c=5, 5N HCl) |
| Umsebenzi wokubona | [α]23/D −32.0 kuya ku-−24.0°, c = 8 ku-6 M HCl |
Abesifazane abane-antiphospholipid syndrome (APS) basengozini eyengeziwe yokulahlekelwa ukukhulelwa okuphindaphindiwe (RPL) kanye ne-preeclampsia.Amasosha omzimba e-Antiphospholipid (aPL) ashintsha ngokuqondile umsebenzi we-trophoblast.Ukwelashwa nge-low molecular weight heparin (LMWH) kunciphisa ubungozi be-RPL kodwa hhayi i-preeclampsia.Ngaphezu kwalokho, i-LMWH ivuselela ukukhululwa kwe-trophoblast sFlt-1, into elwa ne-angiogenic ehlobene ne-preeclampsia.Njengoba ukuntuleka kwevithamini D kuhlotshaniswa ne-APS kanye ne-preeclampsia, lolu cwaningo lufuna ukunquma umphumela we-vitamin D ekusebenzeni kwe-trophoblast esimweni se-aPL kanye ne-LMWH.A human first trimester trophoblast cell line (HTR8) kanye namasiko e-primary trophoblast alashwa noma ngaphandle kwe-aPL lapho kukhona kanye nokungabikho kwevithamini D, i-LMWH noma kokubili.I-Trophoblast secretion yama-cytokines avuthayo kanye nezici ze-angiogenic zikalwa nge-ELISA.I-Vitamin D iyodwa noma ihlanganiswe ne-LMWH yanciphisa impendulo yokuvuvukala ye-trophoblast eyenziwe nge-aPL kumaseli e-HTR8 namasiko ayisisekelo.Nakuba i-vitamin D ingazange ibe nomthelela ekuguqulweni kwe-aPL-mediated kwezici ze-angiogenic ku-trophoblast eyinhloko, ivimbele ngokuphawulekayo ukukhululwa kwe-LMWH-induced sFlt-1. I-LMWH ihlanganiswe ne-vitamin D ingase ibe nenzuzo kakhulu kunokwelashwa kwe-ejenti eyodwa ngokuvimbela i-aPL -ukuvuvukala kwe-trophoblast okubangelwa ukuguqulwa kwe-LMWH-induced sFlt-1 secretion.
