I-Diethylene triamine pentaacetic acid Cas: 67-43-6 99% I-crystalline powder emhlophe
| Inombolo Yekhathalogi | I-XD90220 |
| Igama Lomkhiqizo | I-Diethylene triamine pentaacetic acid |
| I-CAS | 67-43-6 |
| I-Molecular Formula | I-C14H23N3O10 |
| Isisindo samangqamuzana | 393.3465 |
| Imininingwane Yesitoreji | I-ambient |
| Ikhodi Yentela Evumelanisiwe | 29224985 |
Ukucaciswa Komkhiqizo
| Izinsimbi ezinzima | 0.001% ubuningi |
| pH | 2-3 |
| Fe | 0.001% ubuningi |
| Ukuncibilika | Incibilika kancane emanzini, isisombululo esingu-15% sincibilika emanzini ashisayo.Incibilika kuyo yonke i-Alkali |
| Isivivinyo | 99% iminithi |
| Umlotha one-sulfate | 0.1% ubuningi |
| Cl | 0.1% ubuningi |
| Ukubukeka | I-crystalline powder emhlophe |
Ukwenyuka kwengcindezi ye-oxidative ngaphansi kwezimo ze-hyperglycemic, ngokusebenzisana kwama-AGE nama-RAGE receptors kanye nokusebenzisa i-interleukin mediated transcription signalling, kubikwe ngomdlavuza.Ukuguqulwa kwamaprotheni kuyacutshungulwa ngeqhaza lawo ekuthuthukisweni nasekuqhubekeleni phambili komdlavuza futhi ukusabela kwe-autoantibody ngokumelene nawo kuthola isithakazelo njengophenyo lokutholwa kwalesi sifo kusenesikhathi.Lolu cwaningo luhlaziye izinguquko ku-histone H1 lapho iguqulwa yi-methylglyoxal (MG) kanye nemithelela yayo ku-auto-immunopathogenesis yomdlavuza.I-histone eguquliwe ibonise ukuguqulwa kwezinsalela ezinephunga elimnandi, yashintsha i-tyrosine microenvironment, i-intermolecular cross linking kanye nokukhiqizwa kwama-AGE.Ibonise ukufihlwa kwamapetshi e-hydrophobic kanye noshintsho lwe-hypsochromic ku-fluorescence ethile ye-ANS.I-MG yenza i-histone H1 ibe yi-oxid ngokunamandla okuholela ekuqongeleleni ama-carbonyl asebenzayo.Izilinganiso ezikude ze-CD ye-UV zibonise ukuthuthukiswa okwenziwe yi-di-carbonyl kwesakhiwo se-alpha kanye nokungeniswa kokuvumelana kweshidi le-beta;kanye nezifundo ze-thermal denaturation (Tm) ziqinisekise ukuzinza kokushisa kwe-histone eguquliwe.Ukuhlaziywa kwe-FTIR kubonise i-amide I band shift, isizukulwane seqembu le-carboxyethyl kanye nokudlidliza kwe-N-Cα ku-histone eguquliwe.Ukuhlaziywa kwe-LCMS kuqinisekise ukwakheka kwe-Nε-(carboxyethyl)lysine kanye nocwaningo lwe-electron microscopic lwembula ukwakheka kwe-amorphous aggregate.I-histone eguquliwe ibonise ukubopha ngokubambisana okushintshile ne-DNA.I-H1 eguquliwe yenza amasosha omzimba angama-titre aphezulu konogwaja kanye ne-IgG yefomu ehlukanisiwe ye-sera yonogwaja abagonywe nge-H1 eguquliwe ibonise ukubophezela okukhethekile nge-immunogen yayo ekuhlaziyeni kwe-Western Blot.I-IgG ehlukanisiwe ne-sera yeziguli ezinomdlavuza wamaphaphu, umdlavuza wendlala yesinye, umdlavuza webele kanye nomdlavuza wesifunda sekhanda nentamo ibonise ukuqashelwa okungcono kwama-neo-epitopes ku-histone eguquliwe, okubonisa ukuba khona kwama-autoantibodies ajikelezayo kumdlavuza.Njengoba imibiko iphakamisa ukuxhumana phakathi kwe-axis ye-AGE-RAGE kanye ne-carcinogenesis, i-glycoxidation ye-histone H1 kanye nokuzivikela kwayo komzimba kuvula izindlela zokuqonda indima yamaprotheni enuzi alimele nge-glycoxidative kumdlavuza.
