I-5-Sulfosalicylic acid dihydrate Cas: 5965-83-3 Ikristalu elimhlophe ukuya kokumhlophe
| Inombolo Yekhathalogi | XD90230 |
| Igama Lomkhiqizo | 5-Sulfosalicylic acid dihydrate |
| I-CAS | 5965-83-3 |
| I-Molecular Formula | I-C7H10O8S |
| Isisindo samangqamuzana | 254.215 |
| Imininingwane Yesitoreji | I-ambient |
| Ikhodi Yentela Evumelanisiwe | 29182900 |
Ukucaciswa Komkhiqizo
| I-sulfate | 5.5% ubuningi |
| Umswakama | 22% ubuningi |
| Ukubukeka | Ikristalu elimhlophe ukuya kokumhlophe |
| Iasidi ephelele | 99 - 104% |
| Isivivinyo | 99% |
Ama-polycation ahlolwa njengabathwali ukuletha i-nucleic acid yokwelapha.Ama-polycations ajwayelekile ngokwesayensi ye-pharmacological inert enomsebenzi owodwa wokuletha impahla yokwelapha.Lolu cwaningo lubika ukuhlanganiswa kwe-self-immolative polycation (DSS-BEN) esekelwe kusidakamizwa se-polyamine analogue N(1),N(11)-bisethylnorspermine (BENSpm).I-polycation yayiklanyelwe ukusebenza ngokubili njengesithwali sokuletha izakhi zofuzo kanye ne-prodrug eqondise i-dysregulated polyamine metabolism kumdlavuza.Sisebenzisa inhlanganisela ye-NMR ne-HPLC, siqinisekisa ukuthi i-self-immolative polycation ithola ukuwohloka kwe-intracellular ibe isidakamizwa esingumzali i-BENSpm.I-BENSpm ekhululiwe iqeda amazinga eselula e-spermidine ne-spermine futhi ilawula i-polyamine catabolic enzymes i-spermine/spermidine N(1)-acetyltransferase (SSAT) kanye ne-spermine oxidase (SMO).Ama-polycations ahlanganisiwe akha ama-polyplexes ane-DNA futhi enze kube lula ukudluliswa kwegciwane.Ukusebenzisa ikhono le-BENSpm ukuqwashisa amaseli omdlavuza kuma-apoptos enziwe yi-TNFα, sibonisa ukuthi i-DSS-BEN ithuthukisa umsebenzi wokubulala amaseli we-TNFα gene therapy.Okutholakele okubikiwe kuqinisekisa i-DSS-BEN njengohlelo lokuletha olusebenza kabili olungaletha isakhi sofuzo lokwelapha futhi luthuthukise umphumela wokwelashwa kofuzo ngenxa yokuwohloka kwe-intracellular ye-DSS-BEN kuya ku-BENSpm kanye nomphumela onenzuzo owalandela we-BENSpm ku-polyamine engalawuleki. i-metabolism kumdlavuza.
