I-Folic Acid Cas: 59-30-3 99%
| Inombolo Yekhathalogi | XD90435 |
| Igama Lomkhiqizo | I-Folic Acid |
| I-CAS | 59-30-3 |
| I-Molecular Formula | I-C19H19N7O6 |
| Isisindo samangqamuzana | 441.40 |
| Imininingwane Yesitoreji | I-ambient |
| Ikhodi Yentela Evumelanisiwe | 29362900 |
Ukucaciswa Komkhiqizo
| Ukubukeka | I-crystalline powder ephuzi noma ewolintshi |
| Isivivinyo | 99% |
| Amanzi | 5.0 - 8.5% |
| Ubumsulwa beChromatographic | <2.0% |
| Ukuncibilika | Ayincibiliki emanzini nasezincibilikilweni eziningi eziphilayo.Incibilika kuma-asidi acwebileyo nasezixazululweni ze-alkaline |
| Izinsalela ekushiseni | <0.3% |
Kulolu cwaningo, i-thermosensitive ne-folate functionalized poly(ethylene oxide) -b-poly(propylene oxide)-b-poly(ethylene oxide) -ploy(N-isopropylacrylamide-co-hydroxyethyl methacrylate) (FA-Pluronic-PNH) copolymer kuhlanganiswe.Isakhiwo nesisindo samangqamuzana se-copolymer kuqinisekiswe yi-1H NMR, FT-IR kanye ne-GPC, ngokulandelana.Izinga lokushisa eliphansi lesixazululo esibucayi (LCST) le-copolymer lalingu-39.8 degrees C. Ngokusebenzisa i-doxorubicin (DOX) njengesidakamizwa esiyimodeli, ama-micelles alayishwe i-DOX ahloselwe i-folate aphinde akhiwa ku-copolymer.Ama-micelles angenalutho kanye ne-DOX alayishwe womabili abonisa izimo ezicishe zibe yindilinga futhi ububanzi bawo obumaphakathi bube ngu-35 nm no-50 nm, ngokulandelana.Ukuziphatha kokukhishwa kwe-in vitro kwama-micelles alayishwe i-DOX bekuncike kuzinga lokushisa futhi izinga lokukhishwa kwe-DOX ku-42 degrees C (ngaphezulu kwe-LCST) lalishesha kunalelo ku-37 degrees C (ngezansi kwe-LCST).Ngaphezu kwalokho, ukuhlolwa kwe-cytotoxicity kwama-micelles alayishiwe e-DOX kanye ne-DOX yamahhala emigqeni yamaseli omdlavuza womlomo wesibeletho womuntu i-HeLa kanye nemigqa yamaseli omdlavuza wamaphaphu womuntu i-A549 ibonise ukuthi i-folate ikhuphule ukutholwa kwamaseli kumaseli ngaphakathi kwamaseli okuhlosiwe aveza kakhulu ama-folate receptors.
