I-Furazolidone Cas: 67-45-8
| Inombolo Yekhathalogi | XD91885 |
| Igama Lomkhiqizo | I-Furazolidone |
| I-CAS | 67-45-8 |
| Ifomu le-Molecularla | I-C8H7N3O5 |
| Isisindo samangqamuzana | 225.16 |
| Imininingwane Yesitoreji | I-ambient |
| Ikhodi Yentela Evumelanisiwe | 29349990 |
Ukucaciswa Komkhiqizo
| Ukubukeka | Impushana ephuzi |
| U-Asay | 99% iminithi |
| Iphoyinti lokuncibilika | 254-256°C (dec.) |
| Iphuzu elibilayo | 366.66°C (isilinganiso esinzima) |
| ukuminyana | 1.5406 (isilinganiso esinzima) |
| inkomba ye-refractive | 1.7180 (isilinganiso) |
| Fp | 2 °C |
| ukuncibilika | i-fomic acid: i-soluble50mg/mL |
| pka | -1.98±0.20(Kubikezelwe) |
| Kuyazwela | Ukukhanya Okuzwelayo |
| λ ubuningi | 365nm(DMSO)(lit.) |
| Ukuzinza | Izinzile.Okuvuthayo.Akuhambisani nama-oxidizing agents aqinile. |
I-spectrum ye-antibacterial ye-furazolidone ifana ne-furazolidone.Njengesidakamizwa esilwa nokutheleleka, sisebenza ngempumelelo ekwelapheni i-Salmonella, i-Shigella, i-Escherichia coli, i-Proteus, i-Streptococcus, ne-Staphylococcus aureus.Amagciwane akulula ukuthuthukisa ukumelana nomuthi lo muthi.Futhi ayinakho ukumelana nemithi elwa namagciwane ekilasi le-sulfa.Ngokuyinhloko isetshenziselwa ukwelashwa kwe-dysentery, enteritis, typhoid, paratyphoid kanye nokwelashwa kwe-topical trichomoniasis yangasese.
2. Umkhiqizo uyisibulala-sikhunta esinomthamo obanzi wokulwa namagciwane.Njengomuthi oqeda ukutheleleka, uyasebenza ekwelapheni amagciwane ahlukahlukene e-Gram-positive kanye nama-negative ahlanganisa i-Escherichia coli, i-Bacillus anthracis, ne-Paratyphoid bacilli.Ayisebenzi nje kuphela ekwelapheni isifo sohudo, i-enteritis, kodwa futhi isetshenziselwa ukwelapha izifo zangasese.Eminyakeni yamuva, iyasebenza kahle ekwelapheni i-typhoid fever.Njengesengezo sezidakamizwa neziphuzo zezilwane, inomphumela oyingqayizivele we-antibacterial ku-Salmonella, i-Escherichia coli ne-Salmonella pullorum futhi inomphumela othile ovimbelayo ku-protozoa (i-coccidia bacteria, njll.) futhi ibenze bangabi lula ekuguqukeni ukumelana nezidakamizwa.Inani elincane le-furazolidone lisetshenziswe kwezinye izinhlelo zokusebenza (njengopende oncibilika emanzini kanye ne-pulp yephepha) njengezibulala-fungi.
3. Yisidakamizwa esilwa namagciwane esisetshenziselwa ukulwa namagciwane emathunjini.
4. I-Furazolidone, njenge-fungicide, ine-spectrum ebanzi ye-antibacterial.Amagciwane athinteka kakhulu yi-Escherichia coli, i-Bacillus anthracis, i-paratyphoid rod, i-Shigella, ne-Klebsiella pneumoniae.I-Salmonella typhi nayo iyazwela kuyo.Isetshenziselwa ikakhulukazi ukwelapha isifo sohudo esibangelwa amagciwane, i-enteritis, nekholera.Ingasetshenziswa futhi ekwelapheni i-typhoid, i-paratyphoid, i-giardiasis, ne-trichomoniasis.Inhlanganisela nemithi elwa ne-asidi ingasetshenziselwa ukwelapha ukuvuvukala kwesisu okubangelwa yi-Helicobacter pylori.Izakhiwo: Impushana ephuzi noma i-crystalline powder, ayinaphunga, iqala ngokunganambitheki bese iba munyu kancane;incibilika kancane kakhulu emanzini ne-ethanol;i-soluble kancane ku-chloroform futhi ayincibiliki ku-ether, inyibilika ku-dimethylformamide ne-nitromethane.Mp: 255 kuya ku-259 °C.Ukubola ngenkathi ukuqedwa.
I-Furazolidone isetshenziselwa izifo zesisu kanye ne-vaginitis.Isetshenziswa kakhulu emazweni asathuthuka ukwelapha izifo zohudo ze-etiology ehlukahlukene, kodwa akusiyo isidakamizwa esikhethwayo uma i-pathogen ethile ikhonjwe.Ukusetshenziswa njenge-ejenti yomugqa wesibili ku-giardiasis futhi njengengxenye yemithi yezidakamizwa eziningi ekuthelelekeni kwe-Helicobacter kuye kwakhuthazwa.
3--[(5-Nitrofurylidene)amino]-2-oxazolidinone (Furoxone) yenzeka njengempushana ekristale ephuzi enambitheka ebabayo.Ayincibiliki emanzini noma etshwaleni.I-Furazolidone inomsebenzi we-bactericidal ngokumelene nohlu olubanzi lwe-intestinal pathogens, okuhlanganisa i-S. aureus, E. coli, i-Salmonella, i-Shigella, i-Proteus spp., i-Enterobacter, ne-Vibrio cholerae.Iyasebenza futhi ngokumelene ne-protozoan Giardia lamblia.Kunconywa ekwelapheni ngomlomo isifo sohudo esibangelwa amagciwane noma i-protozoal ebangelwa izinto ezithintekayo.Umthamo ojwayelekile wabantu abadala ngu-100 mg izikhathi ezi-4 ngosuku.
Ingxenyana encane kuphela yomthamo olawulwa ngomlomo we-furazolidoneis emuncwa.Cishe u-5% womthamo womlomo uyabonakala emchameni ngendlela yama-metabolites amaningana.Okunye ukucindezeleka kwamathumbu kuye kwabikwa ngokusetshenziswa kwawo.Utshwala kufanele bugwenywe lapho kusetshenziswa i-furazolidonengoba umuthi ungavimbela i-aldehyde dehydrogenase.
